Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging

• Published in: Cancer Vol. 56; no. 4; pp. 956 - 960
• Main Authors: Potish, Roger A., Twiggs, Leo B., Okagaki, Takashi, Prem, Konald A., Adcock, Leon L.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 15.08.1985; Wiley-Liss
• Subjects: Adult; Aged; Biological and medical sciences; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Intestines - radiation effects; Lymphatic Metastasis; Medical sciences; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging - methods; Preoperative Care; Prognosis; Radiation Injuries; Time Factors; Tumors; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; Uterine Cervical Neoplasms - surgery; Human; Treatment; Surgery; Gynecology; Evolution; Advanced stage; Tumor; Uterine cervix; Preoperative; History; Female genital diseases
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(19850815)56:4<956::AID-CNCR2820560442>3.0.CO;2-U

From 1978 to 1983, 112 women with advanced cervical carcinomas received radiotherapy after pretreatment surgical staging. Five‐year actuarial relapse‐free survival rates were a strong function of lymphatic spread: 40% with periaortic node metastases, 50% with pelvic node metastases, and 84% without node metastases. Primary treatment failure had a distant component in 75% of recurrences (50% of recurrences with negative nodes and 85% of recurrences with positive nodes). It was concluded that adjuvant systemic therapy is necessary to substantially raise the probability of cure.