Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats
Two milliliters of a fermented, pasteurized orange juice containing ∼1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC‐mass spectrometry. The main constituents in the juice were hesperetin an...
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| Published in | BioFactors (Oxford) Vol. 40; no. 3; pp. 327 - 335 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Blackwell Publishing Ltd
01.05.2014
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| Abstract | Two milliliters of a fermented, pasteurized orange juice containing ∼1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC‐mass spectrometry. The main constituents in the juice were hesperetin and naringenin‐O‐glycosides, apigenin‐6,8‐C‐diglucoside, and ferulic acid‐4′‐O‐glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin‐7‐O‐glucuronide, naringenin‐4′‐O‐glucuronide, and an isosakuranetin‐O‐glucuronide, peaking 6 h after intake at concentrations of ∼10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid‐4'‐O‐glucuronide and dihydroferulic acid‐4′‐O‐sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid‐4′‐glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion. © 2013 BioFactors, 40(3):327–335, 2014 |
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| AbstractList | Two milliliters of a fermented, pasteurized orange juice containing ~1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC-mass spectrometry. The main constituents in the juice were hesperetin and naringenin-O-glycosides, apigenin-6,8-C-diglucoside, and ferulic acid-4'-O-glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin-7-O-glucuronide, naringenin-4'-O-glucuronide, and an isosakuranetin-O-glucuronide, peaking 6 h after intake at concentrations of ~10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid-4'-O-glucuronide and dihydroferulic acid-4'-O-sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid-4'-glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion. Two milliliters of a fermented, pasteurized orange juice containing 1% alcohol and 2.3 mu mol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC-mass spectrometry. The main constituents in the juice were hesperetin and naringenin-O-glycosides, apigenin-6,8-C-diglucoside, and ferulic acid-4'-O-glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin-7-O-glucuronide, naringenin-4'-O-glucuronide, and an isosakuranetin-O-glucuronide, peaking 6 h after intake at concentrations of 10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid-4'-O-glucuronide and dihydroferulic acid-4'-O-sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid-4'-glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion. copyright 2013 BioFactors, 40(3):327-335, 2014 Two milliliters of a fermented, pasteurized orange juice containing ∼1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC‐mass spectrometry. The main constituents in the juice were hesperetin and naringenin‐O‐glycosides, apigenin‐6,8‐C‐diglucoside, and ferulic acid‐4′‐O‐glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin‐7‐O‐glucuronide, naringenin‐4′‐O‐glucuronide, and an isosakuranetin‐O‐glucuronide, peaking 6 h after intake at concentrations of ∼10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid‐4'‐O‐glucuronide and dihydroferulic acid‐4′‐O‐sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid‐4′‐glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion. © 2013 BioFactors, 40(3):327–335, 2014 Abstract Two milliliters of a fermented, pasteurized orange juice containing ∼1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which plasma and urine collected over a 36 h period were analyzed by UHPLC‐mass spectrometry. The main constituents in the juice were hesperetin and naringenin‐ O ‐glycosides, apigenin‐6,8‐ C ‐diglucoside, and ferulic acid‐4′‐ O ‐glucoside. Plasma contained seven flavanone glucuronides, with the principal metabolites, naringenin‐7‐ O ‐glucuronide, naringenin‐4′‐ O ‐glucuronide, and an isosakuranetin‐ O ‐glucuronide, peaking 6 h after intake at concentrations of ∼10 nmol/L. Urinary excretion of four hesperetin glucuronides was equivalent to 0.28% of intake while that of the two naringenin glucuronides was 2.8% of intake. The plasma and urine data suggest that while some absorption occurred in the small intestine, the main site of uptake was the colon. Urine also contained dihydroferulic acid‐4'‐ O ‐glucuronide and dihydroferulic acid‐4′‐ O ‐sulfate which were excreted in quantities corresponding to 48.2% of the ingested ferulic acid‐4′‐glucoside. This indicates that the hydroxycinnamate is much more bioavailable than the flavanones in the rat model. Conversion of the ferulic acid glucoside to the dihydroferulic acid metabolites involves the action of colonic microbial glycosidases and reductases/hydrogenases followed by postabsorption phase II metabolism before renal excretion. © 2013 BioFactors, 40(3):327–335, 2014 |
| Author | Calani, Luca Escudero-López, Blanca Fernández-Pachón, María-Soledad Ortega, Ángeles Del Rio, Daniele Brighenti, Furio Crozier, Alan |
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| Keywords | orange juice hydroxycinnamates urinary excretion bioavailability colon microbiota rats flavanones |
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| Snippet | Two milliliters of a fermented, pasteurized orange juice containing ∼1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which... Two milliliters of a fermented, pasteurized orange juice containing ~1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage after which... Abstract Two milliliters of a fermented, pasteurized orange juice containing ∼1% alcohol and 2.3 μmol of (poly)phenolic compounds was fed to rats by gavage... Two milliliters of a fermented, pasteurized orange juice containing 1% alcohol and 2.3 mu mol of (poly)phenolic compounds was fed to rats by gavage after which... |
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| Title | Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats |
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