Proton pump inhibitors and acute interstitial nephritis: Report and analysis of 15 cases

• Published in: Nephrology (Carlton, Vic.) Vol. 11; no. 5; pp. 381 - 385
• Main Authors: SIMPSON, IAN J, MARSHALL, MARK R, PILMORE, HELEN, MANLEY, PAUL, WILLIAMS, LAURIE, THEIN, HLA, VOSS, DAVID
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.10.2006
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects; acute interstitial nephritis; Acute Kidney Injury - chemically induced; Acute Kidney Injury - epidemiology; Acute Kidney Injury - pathology; Aged; Aged, 80 and over; Anti-Ulcer Agents - adverse effects; Biopsy; Blood Sedimentation; C-Reactive Protein - metabolism; Enzyme Inhibitors - adverse effects; Female; Humans; Male; Middle Aged; Nephritis, Interstitial - chemically induced; Nephritis, Interstitial - epidemiology; Nephritis, Interstitial - pathology; omeprazole; Omeprazole - adverse effects; pantoprazole; Proton Pump Inhibitors; renal failure; Risk Factors; tubulo-interstitial nephritis

Aim:  Although proton pump inhibitors (PPI) are usually safe and effective therapeutic agents, serious adverse effects can occur. The aim of the present study was to report and analyse the clinical features of 15 patients with acute interstitial nephritis (AIN) and acute renal failure from PPI that...