Role for the Ankyrin eukaryotic-like genes of Legionella pneumophila in parasitism of protozoan hosts and human macrophages

• Published in: Environmental microbiology Vol. 10; no. 6; pp. 1460 - 1474
• Main Authors: Habyarimana, Fabien, Al-khodor, Souhaila, Kalia, Awdhesh, Graham, James E, Price, Christopher T, Garcia, Maria Teresa, Kwaik, Yousef Abu
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.06.2008; Blackwell Publishing Ltd
• Subjects: Animals; Ankyrins - genetics; Ankyrins - physiology; Bacterial Proteins - genetics; Bacterial Proteins - physiology; Cell Line; Cells, Cultured; Colony Count, Microbial; Eukaryota - microbiology; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Gene Order; Genes, Bacterial; Humans; Legionella pneumophila - genetics; Legionella pneumophila - growth & development; Legionella pneumophila - pathogenicity; Macrophages - microbiology; Repetitive Sequences, Amino Acid; Sigma Factor - physiology; Virulence; Virulence Factors - genetics; Virulence Factors - physiology

Legionella pneumophila is a ubiquitous organism in the aquatic environment where it is capable of invasion and intracellular proliferation within various protozoan species and is also capable of causing pneumonia in humans. In silico analysis showed that the three sequenced L. pneumophila genomes ea...