Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM-1 and HLA-DR by nasal epithelial cells

• Published in: Allergy (Copenhagen) Vol. 50; no. 3; p. 200
• Main Authors: Vignola, A M, Crampette, L, Mondain, M, Sauvère, G, Czarlewski, W, Bousquet, J, Campbell, A M
• Format: Journal Article
• Language: English
• Published: Denmark 01.03.1995
• Subjects: Adult; Histamine - pharmacology; Histamine H1 Antagonists - pharmacology; HLA-DR Antigens - biosynthesis; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1 - biosynthesis; Loratadine - pharmacology; Middle Aged; Nasal Mucosa - drug effects; Nasal Mucosa - immunology; Nasal Polyps - drug therapy; Nasal Polyps - immunology; Piperidines - pharmacology; Pyridines - pharmacology; Turbinates - drug effects; Turbinates - immunology

Nasal epithelial cells represent the first barrier against noxious agents and allergens. In allergic rhinitis, these cells are activated and histamine may be involved in this activation. Loratadine and one of its active metabolites, descarboethoxyloratadine, were studied for their ability to reduce...