Antigen‐Specific β‐Chemokine Production and CD8+ T‐Cell Noncytotoxic Antiviral Activity in HIV‐2‐Infected Individuals
Human immunodeficiency virus‐2 (HIV‐2) is less pathogenic than HIV‐1, and the disease progression in HIV‐2‐infected individuals seems to be similar to that seen in HIV‐1‐infected long‐term nonprogressors. Cell‐mediated immune responses and the production of noncytotoxic CD8+ T‐cell antiviral factors...
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| Published in | Scandinavian journal of immunology Vol. 61; no. 1; pp. 63 - 71 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK; Malden, USA
Blackwell Science Ltd
01.01.2005
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0300-9475 1365-3083 1365-3083 |
| DOI | 10.1111/j.0300-9475.2005.01530.x |
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| Abstract | Human immunodeficiency virus‐2 (HIV‐2) is less pathogenic than HIV‐1, and the disease progression in HIV‐2‐infected individuals seems to be similar to that seen in HIV‐1‐infected long‐term nonprogressors. Cell‐mediated immune responses and the production of noncytotoxic CD8+ T‐cell antiviral factors (CAF) and β‐chemokines have been correlated to protection against HIV‐1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen‐induced β‐chemokine production in HIV‐2‐infected patients living in Sweden and in Guinea‐Bissau. We also compared in vitro CD8+ T‐cell‐mediated noncytotoxic antiviral activity against β‐chemokine‐sensitive R5 virus (HIV‐1Bal) and β‐chemokine‐insensitive X4 virus (HIV‐1IIIB) in HIV‐2‐infected patients with that in HIV‐1‐infected patients. HIV‐2‐specific β‐chemokine production was demonstrated in a majority of the HIV‐2‐infected subjects. CD8+ T cells of both HIV‐1 and HIV‐2‐infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV‐2‐infected patients compared to HIV‐1‐infected subjects. Taken together, our results indicate that the production of CD8+ T‐cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV‐2‐infected patients. |
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| AbstractList | Human immunodeficiency virus‐2 (HIV‐2) is less pathogenic than HIV‐1, and the disease progression in HIV‐2‐infected individuals seems to be similar to that seen in HIV‐1‐infected long‐term nonprogressors. Cell‐mediated immune responses and the production of noncytotoxic CD8+ T‐cell antiviral factors (CAF) and β‐chemokines have been correlated to protection against HIV‐1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen‐induced β‐chemokine production in HIV‐2‐infected patients living in Sweden and in Guinea‐Bissau. We also compared in vitro CD8+ T‐cell‐mediated noncytotoxic antiviral activity against β‐chemokine‐sensitive R5 virus (HIV‐1Bal) and β‐chemokine‐insensitive X4 virus (HIV‐1IIIB) in HIV‐2‐infected patients with that in HIV‐1‐infected patients. HIV‐2‐specific β‐chemokine production was demonstrated in a majority of the HIV‐2‐infected subjects. CD8+ T cells of both HIV‐1 and HIV‐2‐infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV‐2‐infected patients compared to HIV‐1‐infected subjects. Taken together, our results indicate that the production of CD8+ T‐cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV‐2‐infected patients. Human immunodeficiency virus‐2 (HIV‐2) is less pathogenic than HIV‐1, and the disease progression in HIV‐2‐infected individuals seems to be similar to that seen in HIV‐1‐infected long‐term nonprogressors. Cell‐mediated immune responses and the production of noncytotoxic CD8 + T‐cell antiviral factors (CAF) and β‐chemokines have been correlated to protection against HIV‐1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen‐induced β‐chemokine production in HIV‐2‐infected patients living in Sweden and in Guinea‐Bissau. We also compared in vitro CD8 + T‐cell‐mediated noncytotoxic antiviral activity against β‐chemokine‐sensitive R5 virus (HIV‐1 Bal ) and β‐chemokine‐insensitive X4 virus (HIV‐1 IIIB ) in HIV‐2‐infected patients with that in HIV‐1‐infected patients. HIV‐2‐specific β‐chemokine production was demonstrated in a majority of the HIV‐2‐infected subjects. CD8 + T cells of both HIV‐1 and HIV‐2‐infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV‐2‐infected patients compared to HIV‐1‐infected subjects. Taken together, our results indicate that the production of CD8 + T‐cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV‐2‐infected patients. Human immunodeficiency virus-2 (HIV-2) is less pathogenic than HIV-1, and the disease progression in HIV-2-infected individuals seems to be similar to that seen in HIV-1-infected long-term nonprogressors. Cell-mediated immune responses and the production of noncytotoxic CD8(+) T-cell antiviral factors (CAF) and beta-chemokines have been correlated to protection against HIV-1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen-induced beta-chemokine production in HIV-2-infected patients living in Sweden and in Guinea-Bissau. We also compared in vitro CD8(+) T-cell-mediated noncytotoxic antiviral activity against beta-chemokine-sensitive R5 virus (HIV-1(Bal)) and beta-chemokine-insensitive X4 virus (HIV-1(IIIB)) in HIV-2-infected patients with that in HIV-1-infected patients. HIV-2-specific beta-chemokine production was demonstrated in a majority of the HIV-2-infected subjects. CD8(+) T cells of both HIV-1 and HIV-2-infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV-2-infected patients compared to HIV-1-infected subjects. Taken together, our results indicate that the production of CD8(+) T-cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV-2-infected patients. Human immunodeficiency virus-2 (HIV-2) is less pathogenic than HIV-1, and the disease progression in HIV-2-infected individuals seems to be similar to that seen in HIV-1-infected long-term nonprogressors. Cell-mediated immune responses and the production of noncytotoxic CD8+ T-cell antiviral factors (CAF) and beta-chemokines have been correlated to protection against HIV-1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen-induced beta-chemokine production in HIV-2-infected patients living in Sweden and in Guinea-Bissau. We also compared in vitro CD8+ T-cell-mediated noncytotoxic antiviral activity against beta-chemokine-sensitive R5 virus (HIV-1Bal) and beta-chemokine-insensitive X4 virus (HIV-1IIIB) in HIV-2-infected patients with that in HIV-1-infected patients. HIV-2-specific beta-chemokine production was demonstrated in a majority of the HIV-2-infected subjects. CD8+ T cells of both HIV-1 and HIV-2-infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV-2-infected patients compared to HIV-1-infected subjects. Taken together, our results indicate that the production of CD8+ T-cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV-2-infected patients. Human immunodeficiency virus-2 (HIV-2) is less pathogenic than HIV-1, and the disease progression in HIV-2-infected individuals seems to be similar to that seen in HIV-1-infected long-term nonprogressors. Cell-mediated immune responses and the production of noncytotoxic CD8+ T-cell antiviral factors (CAF) and beta-chemokines have been correlated to protection against HIV-1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen-induced beta-chemokine production in HIV-2-infected patients living in Sweden and in Guinea-Bissau. We also compared in vitro CD8+ T-cell-mediated noncytotoxic antiviral activity against beta-chemokine-sensitive R5 virus (HIV-1Bal) and beta-chemokine-insensitive X4 virus (HIV-1IIIB) in HIV-2-infected patients with that in HIV-1-infected patients. HIV-2-specific beta-chemokine production was demonstrated in a majority of the HIV-2-infected subjects. CD8+ T cells of both HIV-1 and HIV-2-infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV-2-infected patients compared to HIV-1-infected subjects. Taken together, our results indicate that the production of CD8+ T-cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV-2-infected patients.Human immunodeficiency virus-2 (HIV-2) is less pathogenic than HIV-1, and the disease progression in HIV-2-infected individuals seems to be similar to that seen in HIV-1-infected long-term nonprogressors. Cell-mediated immune responses and the production of noncytotoxic CD8+ T-cell antiviral factors (CAF) and beta-chemokines have been correlated to protection against HIV-1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen-induced beta-chemokine production in HIV-2-infected patients living in Sweden and in Guinea-Bissau. We also compared in vitro CD8+ T-cell-mediated noncytotoxic antiviral activity against beta-chemokine-sensitive R5 virus (HIV-1Bal) and beta-chemokine-insensitive X4 virus (HIV-1IIIB) in HIV-2-infected patients with that in HIV-1-infected patients. HIV-2-specific beta-chemokine production was demonstrated in a majority of the HIV-2-infected subjects. CD8+ T cells of both HIV-1 and HIV-2-infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV-2-infected patients compared to HIV-1-infected subjects. Taken together, our results indicate that the production of CD8+ T-cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV-2-infected patients. |
| Author | Andersson, S. Blaxhult, A. Thorstensson, R. Fredriksson, E.‐L. Biberfeld, G. Norrgren, H. Ahmed, R. K. S. Da Silva, Z. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15644124$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:1930710$$DView record from Swedish Publication Index |
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| Snippet | Human immunodeficiency virus‐2 (HIV‐2) is less pathogenic than HIV‐1, and the disease progression in HIV‐2‐infected individuals seems to be similar to that... Human immunodeficiency virus-2 (HIV-2) is less pathogenic than HIV-1, and the disease progression in HIV-2-infected individuals seems to be similar to that... |
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| SubjectTerms | Adult Basic Medicine CD8-Positive T-Lymphocytes - immunology Chemokine CCL4 Chemokine CCL5 - biosynthesis Chemokines, CC - biosynthesis Female Guinea-Bissau HIV Antigens HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV-1 - pathogenicity HIV-1 - physiology HIV-2 - immunology HIV-2 - pathogenicity HIV-2 - physiology Humans Immunologi inom det medicinska området (Här ingår: Cell- och immunterapi) Immunology in the Medical Area (including Cell and Immunotherapy) In Vitro Techniques Macrophage Inflammatory Proteins - biosynthesis Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Middle Aged Sweden Virus Replication |
| Title | Antigen‐Specific β‐Chemokine Production and CD8+ T‐Cell Noncytotoxic Antiviral Activity in HIV‐2‐Infected Individuals |
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