The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis

• Published in: Cell death discovery Vol. 11; no. 1; pp. 339 - 18
• Main Authors: Guo, Yanan, Xia, Peng, Tian, Yixiao, Fu, Daosen, Hu, Xiaohui, Xie, Kun, Dong, Wenhao, Zhang, Wei, Liu, Disheng, Shen, Rong, Wang, Degui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.07.2025; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/80/458/582; 692/699/249/2510; Apoptosis; Asymptomatic; Autophagy; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell differentiation; Cells; Communication; Gene expression; Homeostasis; Immune privilege; Immune response; Infertility; Inflammation; Life Sciences; Ligands; Macrophages; Polarization; Reproductive system; Sperm; Spermatogenesis; Stem Cells; Testes; Ubiquitin; Ubiquitination

Dysregulated immune responses may erroneously target normal reproductive tissues, thereby compromising the proper functioning of the reproductive system. Macrophages are the most abundant immune cells in the testes, however, the role of macrophages in spermatogenic function is not yet clear. This st...