Gadolinium-based bimodal probes to enhance T1-Weighted magnetic resonance/optical imaging

• Published in: ACTA BIOMATERIALIA Vol. 110; pp. 15 - 36
• Main Authors: Yang, Chang-Tong, Hattiholi, Aishwarya, Selvan, Subramanian Tamil, Yan, Sean Xuexian, Fang, Wei-Wei, Chandrasekharan, Prashant, Koteswaraiah, Podili, Herold, Christian J., Gulyás, Balázs, Aw, Swee Eng, He, Tao, Ng, David Chee Eng, Padmanabhan, Parasuraman
• Format: Journal Article Publication
• Language: English
• Published: England Elsevier Ltd 01.07.2020; Elsevier BV
• Subjects: Bimodality imaging probe; Biocompatibility; Conjugation; Contrast agent; Contrast agents; Contrast Media; Diagnostic systems; Diethylenetriamine pentaacetic acid; Electron spin; Gadolinium; Liposomes; Magnetic moments; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical imaging; Micelles; MRI; Nanomaterials; Nanoparticles; Optical Imaging; Plasma proteins; Polymers; Probes; Relaxation time; Sensitivity; Spatial discrimination; Spatial resolution; Optical imaging; Nanomaterials; Bimodality imaging probe; MRI; Contrast agent

Gd3+-based contrast agents have been extensively used for signal enhancement of T1-weighted magnetic resonance imaging (MRI) due to the large magnetic moment and long electron spin relaxation time of the paramagnetic Gd3+ ion. The key requisites for the development of Gd3+-based contrast agents are...