Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups

• Published in: Breast cancer research : BCR Vol. 18; no. 1; p. 74
• Main Authors: Netanely, Dvir, Avraham, Ayelet, Ben-Baruch, Adit, Evron, Ella, Shamir, Ron
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.07.2016; BioMed Central
• Subjects: Analysis; Breast cancer; Breast Neoplasms - classification; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cluster Analysis; DNA Methylation; Female; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Gene Ontology; Genetic aspects; Humans; Methylation; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Signal Transduction - genetics; Survival Analysis; DNA methylation; Luminal-A; Unsupervised analysis; Clustering; Breast cancer subtypes; RNA-Seq

Breast cancer is a heterogeneous disease comprising several biologically different types, exhibiting diverse responses to treatment. In the past years, gene expression profiling has led to definition of several "intrinsic subtypes" of breast cancer (basal-like, HER2-enriched, luminal-A, lu...