Prenatal maternal immune activation and brain development with relevance to psychiatric disorders

• Published in: Neuroscience Vol. 346; pp. 403 - 408
• Main Authors: Scola, Gustavo, Duong, Angela
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 27.03.2017
• Subjects: Animals; autism; bipolar disorder; Brain - embryology; Brain - immunology; brain development; Female; Humans; inflammation; maternal immune activation; Maternal-Fetal Exchange; Mental Disorders - etiology; Mental Disorders - immunology; Neurology; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - psychology; Prenatal Exposure Delayed Effects - immunology; Prenatal Exposure Delayed Effects - psychology; schizophrenia; brain development; BD; bipolar disorder; MIA; inflammation; maternal immune activation; SCZ; schizophrenia; LPS; autism; lipopolysaccharide

•Maternal infection is linked to increased risk of psychiatric disorders.•Maternal immune activation changes cytokine levels and brain morphology.•Altered cytokine levels are found in subjects with psychiatric disorders. Growing evidence from epidemiological studies strongly suggests maternal infect...