Plasmapheresis, Photopheresis, and Endovenous Immunoglobulin in Acute Antibody-mediated Rejection in Kidney Transplantation

• Published in: Transplantation proceedings Vol. 47; no. 7; pp. 2142 - 2144
• Main Authors: Pretagostini, R., Poli, L., Gozzer, M., Pettorini, L., Garofalo, M., Novelli, S., Cinti, P., Berloco, P.B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015
• Subjects: Adult; Antibodies - adverse effects; Antibodies - blood; Antibodies - immunology; Female; Graft Rejection - immunology; Graft Rejection - therapy; Humans; Immunoglobulins, Intravenous - therapeutic use; Immunosuppression - methods; Kidney Transplantation - adverse effects; Male; Middle Aged; Photopheresis - statistics & numerical data; Plasmapheresis - statistics & numerical data; Surgery; Young Adult

Acute antibody-mediated rejection (AAMR) is the subject of much research. It is diagnosed by C4d staining at biopsy and circulating donor-specific antibodies (DSA). The combination of intensive plasmapheresis and intravenous immunoglobulin (IVIG) has been recognized as an effective treatment for AAM...