Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells

• Published in: Scientific reports Vol. 15; no. 1; pp. 12128 - 14
• Main Authors: Noguchi, Aya, Kimura, Masanobu, Saiki, Yuriko, Ishikawa, Tomohiko, Kokumai, Takashi, Omori, Yuko, Ono, Yusuke, Miszukami, Yusuke, Ishida, Masaharu, Mizuma, Masamichi, Nakagawa, Kei, Unno, Michiaki, Furukawa, Toru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.04.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 631/337; 631/337/572; 631/337/572/2102; 631/67; 631/80; 692/4017; 692/4020; 692/4028; Adenocarcinoma; Cancer; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotherapy; Deoxycytidine - analogs & derivatives; Deoxycytidine - pharmacology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; ETS protein; Extracellular signal-regulated kinase; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene regulation; Humanities and Social Sciences; Humans; K-Ras protein; Kinases; MAP kinase; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3 - metabolism; Molecules; multidisciplinary; Mutation; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Protein c-ets-1 - genetics; Proto-Oncogene Protein c-ets-1 - metabolism; Regulatory sequences; Science; Science (multidisciplinary); Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; Transcriptomes

Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated kinase 1/2 (ERK1/2) driven by gain-of-function mutations of KRAS . Our previous transcriptome sequencing of ERK1/2-attenuated cultured pancreatic cancer cells unveiled nu...