Constituents of the Stem Bark of Symphonia globulifera Linn. f. with Antileishmanial and Antibacterial Activities
The chemical investigation of the -hexane fraction from the methanol extract of the stem bark of Linn f., which displayed good in vitro activity against NR-48822 promastigotes (IC 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U ( ), V ( )...
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Published in | Molecules (Basel, Switzerland) Vol. 28; no. 6; p. 2473 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
08.03.2023
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | The chemical investigation of the
-hexane fraction from the methanol extract of the stem bark of
Linn f., which displayed good in vitro activity against
NR-48822 promastigotes (IC
43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (
), V (
)/W (
), and a new tocotrienol derivative named globuliferanol (
), along with 11 known compounds (
-
). Their structures were elucidated based on their NMR and MS data. Some isolated compounds were assessed for both their antileishmanial and cytotoxic activities against
and Vero cells, respectively. Guttiferone K (
) exhibited the best potency (IC
3.30 μg/mL), but with low selectivity to Vero cells. The
-hexane fraction and some compounds were also assessed in vitro for their antibacterial activity against seven bacterial strains. All the samples exhibited moderate to potent antibacterial activity (MICs ≤ 15.6 µg/mL) against at least one of the tested strains. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules28062473 |