Decreased expression of insulin-degrading enzyme increases gluconeogenesis and glucose production in cultured hepatocytes administered with glucagon - González-Casimiro, Carlos M.; Cámara-Torres, Patricia; Merino, Beatriz; Astudillo, Alma M.; de la Fuente, Miguel A.; Ramírez, Cristina M.; Alonso, Andrés; Cózar-Castellano, Irene; Perdomo, Germán (Scientific reports, 2025)
Keywords: 631/45/776; 631/80/86; Animal tissues; Animals; Blood glucose; Cells, Cultured; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Enzymes; Glucagon; Glucagon - administration & dosage; Glucagon - metabolism; Glucagon - pharmacology; Gluconeogenesis; Gluconeogenesis - drug effects; Gluconeogenesis - genetics; Glucose; Glucose - biosynthesis; Glucose - metabolism; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Hypothesis testing; Insulin; Insulin-degrading enzyme; Insulysin; Insulysin - genetics; Insulysin - metabolism; Liver; Liver - metabolism; Male; Mice; Mice, Knockout; multidisciplinary; Organelles; Phosphorylation; Proteolysis; Receptors, Glucagon - metabolism; Science; Science (multidisciplinary); Signal Transduction; Therapeutic targets; Transcriptomics; Up-regulation; Glucagon; Hepatocytes; Insulin-degrading enzyme; Gluconeogenesis