Fungus-targeted nanomicelles enable microRNA delivery for suppression of virulence in Aspergillus fumigatus as a novel antifungal approach

• Published in: Scientific reports Vol. 15; no. 1; pp. 17398 - 9
• Main Authors: Inukai, Tatsuya, Watanabe, Rikuto, Murakami, Yoshiki, Cabral, Horacio, Kuroda, Masahiko, Nakamura, Shigeki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/193; 639/925/352/152; Alb1 protein; Antifungal agents; Antifungal Agents - pharmacology; Aspergillosis; Aspergillosis - microbiology; Aspergillus fumigatus; Aspergillus fumigatus - drug effects; Aspergillus fumigatus - genetics; Aspergillus fumigatus - metabolism; Aspergillus fumigatus - pathogenicity; Drug delivery systems; Drug development; Fungal Proteins - genetics; Fungal Proteins - metabolism; Fungi; Humanities and Social Sciences; Humans; Hydrogen peroxide; Hypothesis testing; Leukocytes (neutrophilic); Medical innovations; Melanin; Melanins - metabolism; MicroRNAs; MicroRNAs (miRNAs); MicroRNAs - administration & dosage; MicroRNAs - genetics; miRNA; multidisciplinary; Oxidative stress; Oxidative Stress - drug effects; RNA therapeutics; Science; Science (multidisciplinary); Transfection; Virulence - drug effects; Virulence - genetics; Virulence factors; Virulence Factors - genetics; Virulence Factors - metabolism; Western blotting; Drug delivery systems; MicroRNAs (miRNAs); RNA therapeutics; Aspergillus fumigatus

Aspergillus fumigatus , which causes aspergillosis, has developed resistance to azole antifungal agents in recent years. As only three main classes of antifungal drugs are available, the development of novel therapeutic strategies is crucial. We aimed to control the expression of virulence factors b...