An inactivated gE-deleted pseudorabies vaccine provides complete clinical protection and reduces virus shedding against challenge by a Chinese pseudorabies variant

• Published in: BMC veterinary research Vol. 12; no. 1; p. 277
• Main Authors: Wang, Jichun, Guo, Rongli, Qiao, Yongfeng, Xu, Mengwei, Wang, Zhisheng, Liu, Yamei, Gu, Yiqi, Liu, Chang, Hou, Jibo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.12.2016; BioMed Central
• Subjects: Animals; Aujeszky's disease; China; Control; Gene Deletion; Genetic aspects; Herpesviridae - genetics; Herpesviridae - immunology; Nose - virology; Pseudorabies - pathology; Pseudorabies - prevention & control; Pseudorabies - virology; Pseudorabies Vaccines - immunology; Pseudorabies Vaccines - standards; Random Allocation; Swine; Swine Diseases - pathology; Swine Diseases - prevention & control; Swine Diseases - virology; Vaccines; Vaccines, Inactivated - immunology; Vaccines, Inactivated - standards; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; Viral Vaccines - immunology; Viral Vaccines - standards; Virus Shedding - immunology; Pseudorabies virus emerging variant; Bacterial artificial chromosome; gE deletion; Adjuvant; Challenge protection; Inactivated vaccine

Since the end of 2011 an outbreak of pseudorabies affected Chinese pig herds that had been vaccinated with the commercial vaccine made of Bartha K61 strain. It is now clear that the outbreak was caused by an emergent PRV variant. Even though vaccines made of PRV Bartha K61 strain can confer certain...