A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

• Published in: Nature communications Vol. 16; no. 1; pp. 5655 - 14
• Main Authors: Bohnen, Nicolaas I., Roytman, Stiven, van der Zee, Sygrid, Carli, Giulia, Michalakis, Fotini, Luker, Austin, Slingerland, Sofie, Frey, Kirk A., Scott, Peter J. H., Koeppe, Robert A., van Laar, Teus, Albin, Roger L., Kanel, Prabesh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 59/57; 59/78; 631/378/2587; 692/699/375/1718; Acetylcholine - metabolism; Aged; Biology; Brain - diagnostic imaging; Brain - metabolism; Cholinergic transmission; Cholinergics; Cognition & reasoning; Denervation; Disease Progression; Down-regulation; Female; Gait; Humanities and Social Sciences; Humans; Longitudinal Studies; Male; Middle Aged; Movement disorders; multidisciplinary; Neurodegenerative diseases; Parkinson Disease - classification; Parkinson Disease - diagnostic imaging; Parkinson Disease - metabolism; Parkinson's disease; Positron-Emission Tomography; Principal Component Analysis; Principal components analysis; Regions; Science; Science (multidisciplinary); Subgroups; Therapeutic targets; Up-regulation; Variables; Vesicular Acetylcholine Transport Proteins - metabolism; Vesicular acetylcholine transporter; United States > US; Michigan
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-025-60815-0

Parkinson disease (PD) is a heterogeneous syndrome. There is a need for biology-driven subtyping to inform specific therapeutic strategies. In a two-center study with de novo and established PD cohorts, we use vesicular acetylcholine transporter ligand [ 18 F]FEOBV brain PET to assess cholinergic sy...