Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

• Published in: Malaria journal Vol. 15; no. 1; p. 377
• Main Authors: Hickey, Bradley W., Lumsden, Joanne M., Reyes, Sharina, Sedegah, Martha, Hollingdale, Michael R., Freilich, Daniel A., Luke, Thomas C., Charoenvit, Yupin, Goh, Lucy M., Berzins, Mara P., Bebris, Lolita, Sacci, John B., De La Vega, Patricia, Wang, Ruobing, Ganeshan, Harini, Abot, Esteban N., Carucci, Daniel J., Doolan, Denise L., Brice, Gary T., Kumar, Anita, Aguiar, Joao, Nutman, Thomas B., Leitman, Susan F., Hoffman, Stephen L., Epstein, Judith E., Richie, Thomas L.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.07.2016; BioMed Central
• Subjects: Adolescent; Adult; Analysis; Animals; Antibodies, Protozoan - blood; Antigens; Care and treatment; Culicidae - physiology; Dosage and administration; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; Health aspects; Humans; Immunization; Insect Bites and Stings; Malaria; Malaria vaccine; Malaria Vaccines - administration & dosage; Malaria Vaccines - adverse effects; Malaria Vaccines - immunology; Malaria, Falciparum - prevention & control; Male; Middle Aged; Mosquitoes; Plasmodium falciparum; Plasmodium falciparum - immunology; Plasmodium falciparum - radiation effects; Prevention; Sporozoites - immunology; Sporozoites - radiation effects; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Young Adult

In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by mosquito bite and then underwent controlled human malaria infection (CHMI). The PfRAS model for immunization against malaria had previously indu...