Multi-omics analysis identifies LANCL2 as a potential biomarker for the diagnosis and prognosis of gastric cancer

• Published in: Scientific reports Vol. 15; no. 1; pp. 18231 - 18
• Main Authors: Fang, Xidong, Liu, Mengxiao, Ren, Qian, Li, Renpeng, Wu, Guozhi, Yuan, Hao, Zheng, Ya, Gou, Xi, Wang, Yuping, Zhou, Yongning
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/67; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cell cycle; Cell Line, Tumor; Cell proliferation; Disease management; DNA repair; Enzymes; Female; Ferroptosis; Gastric cancer; Gene Expression Regulation, Neoplastic; Gene set enrichment analysis; Guanylate cyclase; Humanities and Social Sciences; Humans; Immune checkpoint; LANCL2; Male; Malignancy; Medical prognosis; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metastases; Middle Aged; Morbidity; mRNA; multidisciplinary; Multiomics; Pathogenesis; Prognosis; Public health; Science; Science (multidisciplinary); Stomach adenocarcinoma; Stomach Neoplasms - diagnosis; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Therapeutic targets; Tumorigenesis; Tumors; LANCL2; Tumorigenesis; Prognosis; Stomach adenocarcinoma

Gastric cancer (GC) constitutes a significant global public health burden due to its high morbidity rates and poor prognosis, underscoring the critical need for identifying novel therapeutic targets and elucidating their mechanisms. As a key member of the lanthionine synthetase C-like enzyme family,...