Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque - Zhang, Xueyan; Zhou, Baisong; Gong, Yihan; Liu, Yulin (Scientific reports, 2025)
Keywords: 631/154/436; 631/154/51; 692/308/2778; Administration, Intravaginal; Animals; Biological activity; Biological effects; Chinese rhesus macaque; Cross-Over Studies; Drug dosages; Female; Humanities and Social Sciences; Humans; Interferon; Interferon alpha-2 - administration & dosage; Interferon alpha-2 - pharmacokinetics; Interferon alpha-2 - pharmacology; Macaca mulatta; multidisciplinary; Neopterin; Pharmacodynamics; Pharmacokinetics; PK/PD; Process change; Recombinant human interferon Alfa-2b vaginal suppository; Recombinant Proteins - administration & dosage; Recombinant Proteins - pharmacokinetics; Recombinant Proteins - pharmacology; Science; Science (multidisciplinary); Suppositories; Test animals; Umbilicus; Vagina; α-Interferon; β2 Microglobulin; Chinese rhesus macaque; Recombinant human interferon Alfa-2b vaginal suppository; PK/PD; Process change