The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity

• Published in: Malaria journal Vol. 15; no. 1; p. 301
• Main Authors: Chaudhury, Sidhartha, Ockenhouse, Christian F., Regules, Jason A., Dutta, Sheetij, Wallqvist, Anders, Jongert, Erik, Waters, Norman C., Lemiale, Franck, Bergmann-Leitner, Elke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.05.2016; BioMed Central
• Subjects: Antibodies, Protozoan - blood; Cell Line; Cohort Studies; Dosage and administration; Enzyme-Linked Immunosorbent Assay; Humans; Malaria; Malaria - prevention & control; Malaria vaccine; Malaria Vaccines - administration & dosage; Malaria Vaccines - immunology; Opsonin Proteins - blood; Phagocytosis; Prevention; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Epitope; Malaria; Antibody; Protection; Phagocytosis

Recent vaccine studies have shown that the magnitude of an antibody response is often insufficient to explain efficacy, suggesting that characteristics regarding the quality of the antibody response, such as its fine specificity and functional activity, may play a major role in protection. Previous...