Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses

• Published in: Nature communications Vol. 16; no. 1; pp. 6241 - 20
• Main Authors: Dong, Huijun, Pan, Zihang, Jiao, Pengtao, Ye, Fei, Peng, Qi, Yu, Yanying, Lai, Xinyuan, Li, Huan, Guan, Zhao, Deng, Juan, Shen, Tao, Tan, Wenjie, Shi, Yi, Ding, Qiang, Luo, Jianyuan, Li, Tong, Zhuang, Hui, Xiang, Kuanhui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/100; 13/31; 13/89; 14/19; 14/28; 631/250/2499; 631/326/596/4130; 631/532/2117; 64/60; Animals; Coronaviridae; Coronavirus - physiology; Coronaviruses; COVID-19; COVID-19 - virology; Embryo cells; Embryonic Stem Cells - immunology; Embryonic Stem Cells - metabolism; Embryonic Stem Cells - virology; HEK293 Cells; Humanities and Social Sciences; Humans; Interferon; Kinases; Membranes; Mesoderm; Mice; multidisciplinary; Proteins; R-SNARE Proteins - genetics; R-SNARE Proteins - metabolism; Replication; Ribonucleic acid; RNA; RNA, Viral; SARS-CoV-2 - genetics; SARS-CoV-2 - physiology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Stem cells; Transcription; Viral diseases; Viral infections; Virus Replication; Viruses

Embryonic stem cells (ESCs) display a distinctive resistance against various viruses, irrespective of any interferon response. Nevertheless, the underlying mechanism of this resistance remains unclear. In this study, we identify vesicle-associated membrane protein 5 (VAMP5) as a potent cell-autonomo...