Proteomics Profiling Reveals Insulin-Like Growth Factor 1, Collagen Type VI α-2 Chain, and Fermitin Family Homolog 3 as Potential Biomarkers of Plaque Erosion in ST-Segment Elevated Myocardial Infarction

• Published in: Circulation Journal Vol. 84; no. 6; pp. 985 - 993
• Main Authors: Liu, Jinxin, Wang, Shanjie, Hou, Jingbo, Cai, Hengxuan, Pan, Weili, Dong, Haimeng, Sun, Rong, Dong, Hui, Fang, Shaohong, Yu, Bo
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 25.05.2020
• Subjects: Biomarkers - blood; Collagen Type VI - blood; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - diagnostic imaging; High-Throughput Screening Assays; Humans; Insulin-Like Growth Factor I - analysis; Membrane Proteins - blood; Neoplasm Proteins - blood; Optical coherence tomography; Plaque erosion; Plaque rupture; Plaque, Atherosclerotic; Predictive Value of Tests; Prognosis; Proteomics; Retrospective Studies; Rupture, Spontaneous; ST Elevation Myocardial Infarction - blood; ST Elevation Myocardial Infarction - diagnosis; ST Elevation Myocardial Infarction - diagnostic imaging; Tandem Mass Spectrometry; Tandem mass tag; Unstable angina pectoris; Plaque rupture; Optical coherence tomography; Plaque erosion; Unstable angina pectoris; Tandem mass tag

Background:Plaque erosion (PE) has been considered a secondary pathogenesis of ST-segment elevated myocardial infarction (STEMI) following plaque rupture (PR). Previous studies demonstrated that they had different demographic and histology characteristics and need different treatment strategy. But t...