Relationship Between Flow-Metabolism Uncoupling and Evolving Axonal Injury After Experimental Traumatic Brain Injury

• Published in: Journal of cerebral blood flow and metabolism Vol. 24; no. 9; pp. 1025 - 1036
• Main Authors: Chen, Szu-Fu, Richards, Hugh K., Smielewski, Piotr, Johnström, Peter, Salvador, Raymond, Pickard, John D., Harris, Neil G.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.09.2004; Lippincott Williams & Wilkins; Sage Publications Ltd
• Subjects: Amyloid beta-Protein Precursor - metabolism; Animals; Antipyrine - analogs & derivatives; Antipyrine - metabolism; Autoradiography; Axons - metabolism; Axons - pathology; Biological and medical sciences; Brain Injuries - metabolism; Brain Injuries - pathology; Brain Injuries - physiopathology; Carbon Radioisotopes - metabolism; Cerebrovascular Circulation - physiology; Fluorodeoxyglucose F18 - metabolism; Glucose - metabolism; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Medical sciences; Neurology; Rats; Rats, Sprague-Dawley; Vascular diseases and vascular malformations of the nervous system; Uncoupling; Autoradiography; Glucose metabolism; Cortical contusion injury; Blood flow; Nervous system diseases; Uncoupling- Autoradiography-Blood flow-Glucose metabolism- Cortical contusion injury; Central nervous system disease; Metabolism; Trauma; Cerebrovascular disease; Cerebral disorder

Blood flow-metabolism uncoupling is a well-documented phenomenon after traumatic brain injury, but little is known about the direct consequences for white matter. The aim of this study was to quantitatively assess the topographic interrelationship between local cerebral blood flow (LCBF) and glucose...