Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan

• Published in: Nature communications Vol. 16; no. 1; pp. 3973 - 16
• Main Authors: Liu, Yaqi, Brown, Chelsea M., Erramilli, Satchal, Su, Yi-Chia, Guu, Shih-Yun, Tseng, Po-Sen, Wang, Yu-Jen, Duong, Nam Ha, Tokarz, Piotr, Kloss, Brian, Han, Cheng-Ruei, Chen, Hung-Yu, Rodrigues, José, Khoo, Kay-Hooi, Archer, Margarida, Kossiakoff, Anthony A., Lowary, Todd L., Stansfeld, Phillip J., Nygaard, Rie, Mancia, Filippo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.04.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 631/326/41/2536; 631/45/173; 631/535/1258/1259; 82/80; 82/83; Arabinogalactan; Arabinose; Arabinose - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Binding sites; Biosynthesis; Cell Wall - chemistry; Cell Wall - metabolism; Cell walls; Cryoelectron Microscopy; Drug resistance; Galactans - metabolism; Helices; Humanities and Social Sciences; Lipopolysaccharides - chemistry; Lipopolysaccharides - metabolism; Models, Molecular; Molecular dynamics; multidisciplinary; Mycobacterium - metabolism; Mycobacterium tuberculosis - metabolism; Pathogenicity; Pentosyltransferases - chemistry; Pentosyltransferases - genetics; Pentosyltransferases - metabolism; Polysaccharides; Polysaccharides - chemistry; Polysaccharides - metabolism; Reaction mechanisms; Residues; Saccharides; Science; Science (multidisciplinary); Structural analysis; Structure-function relationships; Tuberculosis

The global challenge of tuberculosis, caused by Mycobacterium tuberculosis (Mtb) , is compounded by the emergence of drug-resistant strains. A critical factor in Mtb ’s pathogenicity is its intricate cell envelope, which acts as a formidable barrier against immune defences and pharmacological interv...