Nilotinib treatment induced large granular lymphocyte expansion and maintenance of longitudinal remission in a Philadelphia chromosome-positive acute lymphoblastic leukemia

• Published in: International Journal of Hematology Vol. 111; no. 5; pp. 719 - 723
• Main Authors: Hagihara, Masao, Hua, Jian, Inoue, Morihiro, Uchida, Tomoyuki, Ide, Shiro, Ohara, Shin, Takaku, Tomoiku
• Format: Journal Article
• Language: English
• Published: Singapore Springer Science and Business Media LLC 01.05.2020; Springer Singapore; Springer Nature B.V
• Subjects: Acute lymphoblastic leukemia; Aged; Antineoplastic Combined Chemotherapy Protocols; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bone marrow; Case Report; CD57 antigen; CD57 Antigens; CD8 antigen; CD8-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes - immunology; Central nervous system; Chemotherapy; Chromosomes; Cytotoxicity; Dasatinib; Enzyme inhibitors; Expansion; Hematology; Humans; Immunology; Inhibitor drugs; Kinases; Leukemia; Lymphatic leukemia; Lymphocytes; Lymphocytes - immunology; Lymphocytes T; Lymphocytosis; Medicine; Medicine & Public Health; Multiagent systems; Neoplasm Recurrence, Local; Oncology; Patients; Peripheral blood; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Protein-tyrosine kinase; Pyrimidines; Pyrimidines - administration & dosage; Remission; Remission (Medicine); Remission Induction; Targeted cancer therapy; Time Factors; Treatment Outcome; Tyrosine; Nilotinib; LGLs; Remission; CD57; Ph-ALL

It is well known that the second-generation tyrosine kinase inhibitor dasatinib evokes an immunological reaction as an off-target effect and induces large granular lymphocytes (LGLs) expansion in 30% of patients. However, LGLs expansion in nilotinib-treated patients is rare. We report the case of a...