Repression of Major Histocompatibility Complex Genes by a Human Trophoblast Ribonucleic Acid

• Published in: Biology of reproduction Vol. 60; no. 1; pp. 23 - 31
• Main Author: PEYMAN, J. A
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.01.1999
• Subjects: Base Sequence; Biological and medical sciences; Cell Nucleus - metabolism; DNA, Complementary - chemistry; DNA-Binding Proteins - metabolism; Embryology: invertebrates and vertebrates. Teratology; Fetal membranes; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; General aspects. Development. Fetal membranes; Genes, MHC Class I - genetics; Genes, MHC Class II - genetics; HLA-DR Antigens - genetics; Humans; Intercellular Adhesion Molecule-1 - genetics; Interferon-gamma - pharmacology; Major Histocompatibility Complex - genetics; Microinjections; Molecular Sequence Data; Polymerase Chain Reaction; Repressor Proteins - genetics; Repressor Proteins - physiology; RNA - administration & dosage; STAT1 Transcription Factor; Trans-Activators - metabolism; Transfection; Trophoblasts - chemistry; Untranslated Regions; Human; Trophoblaste; Gene; Intercellular adhesion molecule 1; Fetal membrane; Major histocompatibility system; Class II histocompatibility antigen; Repression; Class I histocompatibility antigen; Gamma interferon

The suppression of polymorphic major histocompatibility complex antigen expression in human trophoblasts is critical for the avoidance of a cell-mediated immune response by maternal lymphocytes against cells expressing paternal antigens. In this study, a repressor of major histocompatibility complex...