MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells

• Published in: Scientific reports Vol. 15; no. 1; pp. 9148 - 11
• Main Authors: Chen, Jingya, Ji, Zhenglei, Wu, Di, Wei, Siyang, Zhu, Wanjing, Peng, Guisen, Hu, Mingjie, Zhao, Yunli, Wu, Huazhang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.03.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/67; 631/80; AKT protein; Apoptosis; BAX protein; Bcl-2 protein; Cancer; Caspase 3 - metabolism; Caspase-3; Cell apoptosis; Cell Cycle; Cell Cycle Proteins; Cell growth; Cell Line, Tumor; Cell Proliferation; Cholecystokinin; Flow cytometry; Gastric cancer; Gene set enrichment analysis; Humanities and Social Sciences; Humans; Lymph nodes; Metastases; multidisciplinary; MYBL2; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; PI3K/AKT signaling pathway; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; Proto-Oncogene Proteins c-myb - metabolism; S phase; Science; Science (multidisciplinary); Signal transduction; Stomach - pathology; Stomach Neoplasms - etiology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Therapeutic targets; Trans-Activators; Transcription factors; Cell proliferation; MYBL2; PI3K/AKT signaling pathway; Gastric cancer; Cell apoptosis

The transcription factor MYB proto-oncogene like 2 (MYBL2) has been reported to be involved in the occurrence and development of various tumors, however, its role in gastric cancer (GC) remains to be elucidated. In this study, the Kaplan-Meier plotter was used to evaluate the prognostic value of dif...