Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants

• Published in: Communications biology Vol. 8; no. 1; pp. 483 - 12
• Main Authors: Anraku, Yuki, Kita, Shunsuke, Onodera, Taishi, Sato, Akihiko, Tadokoro, Takashi, Ito, Shiori, Adachi, Yu, Kotaki, Ryutaro, Suzuki, Tateki, Sasaki, Jiei, Shiwa-Sudo, Nozomi, Iwata-Yoshikawa, Naoko, Nagata, Noriyo, Kobayashi, Souta, Kazuki, Yasuhiro, Oshimura, Mitsuo, Nomura, Takao, Sasaki, Michihito, Orba, Yasuko, Suzuki, Tadaki, Sawa, Hirofumi, Hashiguchi, Takao, Fukuhara, Hideo, Takahashi, Yoshimasa, Maenaka, Katsumi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.03.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596/4130; 631/535/1258/1259; 631/535/1266; 631/61/51/2318; 82/1; 82/103; ACE2; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - therapeutic use; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibodies, Viral - therapeutic use; Biomedical and Life Sciences; COVID-19; COVID-19 - immunology; COVID-19 - therapy; COVID-19 - virology; COVID-19 Drug Treatment; Cricetinae; Cryoelectron Microscopy; Humans; Life Sciences; Medical treatment; Mesocricetus; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Structure-function relationships

Medical treatments using potent neutralizing SARS-CoV-2 antibodies have achieved remarkable improvements in clinical symptoms, changing the situation for the severity of COVID-19 patients. We previously reported an antibody, NT-108 with potent neutralizing activity. However, the structural and funct...