Cardiopulmonary bypass in sickle cell anaemia without exchange transfusion

• Published in: European journal of cardio-thoracic surgery Vol. 14; no. 5; pp. 527 - 529
• Main Authors: Frimpong-Boateng, K., Amoah, A.G.B., Barwasser, H-M., Kallen, C.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Science B.V 01.11.1998; Elsevier Science
• Subjects: Anemia, Sickle Cell - genetics; Anesthesia; Anesthesia depending on type of surgery; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cardiopulmonary bypass; Cardiopulmonary Bypass - methods; Child; Exchange transfusion; Exchange Transfusion, Whole Blood; Female; Haemoglobinopathy; Heart Valve Prosthesis Implantation - methods; Humans; Intraoperative Care - methods; Male; Medical sciences; Mitral Valve Insufficiency - surgery; Sickle cell anaemia; Thoracic and cardiovascular surgery. Cardiopulmonary bypass; Cardiopulmonary bypass; Exchange transfusion; Sickle cell anaemia; Haemoglobinopathy; Human; Hemoglobinopathy; Sickle cell anemia; Transfusion; General anesthesia; Cardiovascular disease; Hemopathy; Replacement; Blood; Genetic disease; Case study; Concomitant disease; Hemolytic anemia; Treatment; Cardiac valvular disease; Surgery; Mitral valve disease; Child
• ISSN: 1010-7940; 1873-734X
• DOI: 10.1016/S1010-7940(98)00198-5

To minimize sickling during cardiopulmonary bypass, exchange transfusion is frequently recommended peri-operatively for patients with homozygous sickle cell anaemia to reduce the circulating concentration of HbS. We report the successful management of two children both aged 12 years with sickle cell anaemia (homozygous SS), several sickle cell crises and multiple blood transfusions who underwent cardiopulmonary bypass for mitral valve replacement. No pre- or intra-operative exchange transfusions were employed in the two cases. Furthermore, moderate hypothermia in both cases was not associated with adverse sequelae.