Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities
The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In the present study, we used the synthetic cDNA of the BASV-G pr...
Saved in:
| Published in | Scientific reports Vol. 15; no. 1; pp. 16285 - 11 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
10.05.2025
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In the present study, we used the synthetic cDNA of the BASV-G protein to develop 4 different types of vaccine, using a recombinant BASV-G protein, a plasmid DNA that expresses the BASV-G protein, a recombinant vaccinia virus that expresses the BASV-G protein, and a pseudotype virus based on hydrogen peroxide-inactivated vesicular stomatitis virus (VSV) that expresses the BASV-G protein (BASVpv). BASVpv was generated and used for the evaluation of neutralizing antibodies and the induction of virus neutralizing antibody upon inoculation (BASVpv/GFP) of these candidates in rabbits. The results showed that both the recombinant vaccinia virus and the hydrogen peroxide-inactivated VLPs effectively induced neutralizing antibodies, even with a single inoculation. |
|---|---|
| AbstractList | The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In the present study, we used the synthetic cDNA of the BASV-G protein to develop 4 different types of vaccine, using a recombinant BASV-G protein, a plasmid DNA that expresses the BASV-G protein, a recombinant vaccinia virus that expresses the BASV-G protein, and a pseudotype virus based on hydrogen peroxide-inactivated vesicular stomatitis virus (VSV) that expresses the BASV-G protein (BASVpv). BASVpv was generated and used for the evaluation of neutralizing antibodies and the induction of virus neutralizing antibody upon inoculation (BASVpv/GFP) of these candidates in rabbits. The results showed that both the recombinant vaccinia virus and the hydrogen peroxide-inactivated VLPs effectively induced neutralizing antibodies, even with a single inoculation. The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In the present study, we used the synthetic cDNA of the BASV-G protein to develop 4 different types of vaccine, using a recombinant BASV-G protein, a plasmid DNA that expresses the BASV-G protein, a recombinant vaccinia virus that expresses the BASV-G protein, and a pseudotype virus based on hydrogen peroxide-inactivated vesicular stomatitis virus (VSV) that expresses the BASV-G protein (BASVpv). BASVpv was generated and used for the evaluation of neutralizing antibodies and the induction of virus neutralizing antibody upon inoculation (BASVpv/GFP) of these candidates in rabbits. The results showed that both the recombinant vaccinia virus and the hydrogen peroxide-inactivated VLPs effectively induced neutralizing antibodies, even with a single inoculation.The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In the present study, we used the synthetic cDNA of the BASV-G protein to develop 4 different types of vaccine, using a recombinant BASV-G protein, a plasmid DNA that expresses the BASV-G protein, a recombinant vaccinia virus that expresses the BASV-G protein, and a pseudotype virus based on hydrogen peroxide-inactivated vesicular stomatitis virus (VSV) that expresses the BASV-G protein (BASVpv). BASVpv was generated and used for the evaluation of neutralizing antibodies and the induction of virus neutralizing antibody upon inoculation (BASVpv/GFP) of these candidates in rabbits. The results showed that both the recombinant vaccinia virus and the hydrogen peroxide-inactivated VLPs effectively induced neutralizing antibodies, even with a single inoculation. Abstract The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In the present study, we used the synthetic cDNA of the BASV-G protein to develop 4 different types of vaccine, using a recombinant BASV-G protein, a plasmid DNA that expresses the BASV-G protein, a recombinant vaccinia virus that expresses the BASV-G protein, and a pseudotype virus based on hydrogen peroxide-inactivated vesicular stomatitis virus (VSV) that expresses the BASV-G protein (BASVpv). BASVpv was generated and used for the evaluation of neutralizing antibodies and the induction of virus neutralizing antibody upon inoculation (BASVpv/GFP) of these candidates in rabbits. The results showed that both the recombinant vaccinia virus and the hydrogen peroxide-inactivated VLPs effectively induced neutralizing antibodies, even with a single inoculation. |
| ArticleNumber | 16285 |
| Author | Morikawa, Shigeru Saijo, Masayuki Park, Eun-Sil Kaku, Yoshihiro Kimura, Masanobu Tani, Hideki Yoshikawa, Tomoki Imaoka, Koichi Maeda, Ken |
| Author_xml | – sequence: 1 givenname: Eun-Sil surname: Park fullname: Park, Eun-Sil email: peunsil@niid.go.jp organization: Department of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 2 givenname: Tomoki surname: Yoshikawa fullname: Yoshikawa, Tomoki organization: Department of Virology I, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 3 givenname: Hideki surname: Tani fullname: Tani, Hideki organization: Department of Virology, Toyama Institute of Health – sequence: 4 givenname: Masanobu surname: Kimura fullname: Kimura, Masanobu organization: Research Center for Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 5 givenname: Yoshihiro surname: Kaku fullname: Kaku, Yoshihiro organization: Department of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 6 givenname: Koichi surname: Imaoka fullname: Imaoka, Koichi organization: Research Center for Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 7 givenname: Ken surname: Maeda fullname: Maeda, Ken organization: Department of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 8 givenname: Masayuki surname: Saijo fullname: Saijo, Masayuki organization: Department of Virology I, National Institute of Infectious Diseases, Japan Institute for Health Security – sequence: 9 givenname: Shigeru surname: Morikawa fullname: Morikawa, Shigeru organization: Department of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Department of Microbiology, Faculty of Veterinary Medicine, Okayama University of Science |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40348847$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kk1vFSEUhompsfXaP-DCkLhxM8r3wMrYGz-aNHGja8IAM-VmBq4wcxv99XI7tbYuZAM5PO97DofzHJzEFD0ALzF6ixGV7wrDXMkGEd4gTDBtbp6AM4IYbwgl5OTB-RScl7JDdXGiGFbPwClDlEnJ2jOQtmnamxxKijD1cL72MES32DmsgeiXOZsx_ApxgCbOoUsu-ALNYEIsM7wwBdoUhwQPIS8FLuUIFn_wVQUPxtoQPZySqx5zFb4AT3szFn9-t2_A908fv22_NFdfP19uP1w1lik2NxYZQaR0kraCti2jQjBBvGWtxQpxJAT31PacCtJx77jve-GEQ0QY0SJF6AZcrr4umZ3e5zCZ_FMnE_RtIOVBmzwHO3qNuaCSYKmQ65hBolOqd8oKYZg1rubegPer137pJu-sj8eWPDJ9fBPDtR7SQWOCBJcUVYc3dw45_Vh8mfUUivXjaKJPS9GUICJ5faeq6Ot_0F1acqy9OlJUCYSxrNSrhyXd1_LnYytAVsDmVEr2_T2CkT4OkF4HSNcB0rcDpG-qiK6iUuE4-Pw3939UvwFQAsix |
| Cites_doi | 10.1038/nm.2763 10.1093/infdis/jir527 10.7883/yoken.JJID.2017.458 10.1128/jvi.00499-24 10.1128/JVI.02178-12 10.1186/s12917-016-0853-y 10.1001/jama.2009.289 10.1128/JVI.01183-13 10.1099/jgv.0.001689 10.1128/JVI.02903-12 10.1126/science.aaa4919 10.1371/journal.ppat.1008859 10.1371/journal.pntd.0011851 10.7883/yoken.JJID.2016.417 10.1371/journal.ppat.1002924 10.1016/j.jviromet.2014.07.003 10.1128/JVI.00512-14 10.1099/vir.0.067108-0 10.1016/S2666-5247(24)00021-1 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2025 2025. The Author(s). Copyright Nature Publishing Group 2025 The Author(s) 2025 2025 |
| Copyright_xml | – notice: The Author(s) 2025 – notice: 2025. The Author(s). – notice: Copyright Nature Publishing Group 2025 – notice: The Author(s) 2025 2025 |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-025-01213-w |
| DatabaseName | Open Access Journals from Springer Nature CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Open Access Journals (DOAJ) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology Veterinary Medicine |
| EISSN | 2045-2322 |
| EndPage | 11 |
| ExternalDocumentID | oai_doaj_org_article_1563821890db4a06b99fd9c66a4cad74 PMC12065830 40348847 10_1038_s41598_025_01213_w |
| Genre | Journal Article Comparative Study |
| GrantInformation_xml | – fundername: Japan Agency for Medical Research and Development grantid: 24fk0108660; 19fk0108072; 19fk0108072 funderid: https://doi.org/10.13039/100009619 – fundername: Japan Society for the Promotion of Science,Japan grantid: 17K18386 – fundername: Japan Society for the Promotion of Science grantid: JP22K08612 funderid: http://dx.doi.org/10.13039/501100001691 – fundername: Japan Agency for Medical Research and Development,Japan grantid: 22fk0108615; 22fk0108615 – fundername: Japan Agency for Medical Research and Development grantid: 19fk0108072 – fundername: Japan Agency for Medical Research and Development grantid: 24fk0108660 – fundername: Japan Agency for Medical Research and Development,Japan grantid: 22fk0108615 – fundername: Japan Society for the Promotion of Science grantid: JP22K08612 |
| GroupedDBID | 0R~ 4.4 53G 5VS 7X7 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD AASML ABDBF ABUWG ACGFS ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AFPKN ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M1P M2P M7P M~E NAO OK1 PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AAYXX CITATION CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 3V. 7XB 88A 8FK AARCD K9. M48 PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c494t-c0a6288d83763774366462ec47c19050665e3cf5362b5ed5eff6d6d026a670923 |
| IEDL.DBID | AAJSJ |
| ISSN | 2045-2322 |
| IngestDate | Wed Aug 27 01:14:12 EDT 2025 Thu Aug 21 18:27:11 EDT 2025 Fri Jul 11 18:06:30 EDT 2025 Wed Aug 13 04:12:16 EDT 2025 Mon Jul 21 06:02:47 EDT 2025 Tue Jul 01 04:54:34 EDT 2025 Sun May 11 01:10:21 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2025. The Author(s). Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c494t-c0a6288d83763774366462ec47c19050665e3cf5362b5ed5eff6d6d026a670923 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.nature.com/articles/s41598-025-01213-w |
| PMID | 40348847 |
| PQID | 3203960118 |
| PQPubID | 2041939 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_1563821890db4a06b99fd9c66a4cad74 pubmedcentral_primary_oai_pubmedcentral_nih_gov_12065830 proquest_miscellaneous_3202857749 proquest_journals_3203960118 pubmed_primary_40348847 crossref_primary_10_1038_s41598_025_01213_w springer_journals_10_1038_s41598_025_01213_w |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2025-05-10 |
| PublicationDateYYYYMMDD | 2025-05-10 |
| PublicationDate_xml | – month: 05 year: 2025 text: 2025-05-10 day: 10 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2025 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | 1213_CR3 ES Park (1213_CR18) 2016; 12 JL Dembinski (1213_CR17) 2014; 207 G Grard (1213_CR2) 2012; 8 T Yoshikawa (1213_CR11) 2021; 17 A Marzi (1213_CR13) 2015; 348 H Tani (1213_CR19) 2014; 88 AK Pinto (1213_CR15) 2013; 87 MM van Oers (1213_CR7) 2015; 96 I Iizuka (1213_CR8) 2017; 70 I Steffen (1213_CR1) 2013; 87 N Omura (1213_CR5) 2018; 71 IJ Amanna (1213_CR14) 2012; 18 JS Kennedy (1213_CR10) 2011; 204 Y Munyeku-Bazitama (1213_CR6) 2024; 98 S Watanabe (1213_CR12) 2023; 17 T Saito (1213_CR9) 2009; 301 Y Munyeku-Bazitama (1213_CR4) 2024; 5 JM Walker (1213_CR16) 2012; 86 |
| References_xml | – volume: 18 start-page: 974 issue: 6 year: 2012 ident: 1213_CR14 publication-title: Nat. Med. doi: 10.1038/nm.2763 – volume: 204 start-page: 1395 issue: 9 year: 2011 ident: 1213_CR10 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jir527 – volume: 71 start-page: 229 issue: 3 year: 2018 ident: 1213_CR5 publication-title: Jpn J. Infect. Dis. doi: 10.7883/yoken.JJID.2017.458 – volume: 98 start-page: e0049924 issue: 7 year: 2024 ident: 1213_CR6 publication-title: J. Virol. doi: 10.1128/jvi.00499-24 – volume: 86 start-page: 13735 issue: 24 year: 2012 ident: 1213_CR16 publication-title: J. Virol. doi: 10.1128/JVI.02178-12 – volume: 12 start-page: 228 issue: 1 year: 2016 ident: 1213_CR18 publication-title: BMC Vet. Res. doi: 10.1186/s12917-016-0853-y – volume: 301 start-page: 1025 issue: 10 year: 2009 ident: 1213_CR9 publication-title: JAMA doi: 10.1001/jama.2009.289 – volume: 87 start-page: 9558 issue: 17 year: 2013 ident: 1213_CR1 publication-title: J. Virol. doi: 10.1128/JVI.01183-13 – ident: 1213_CR3 doi: 10.1099/jgv.0.001689 – volume: 87 start-page: 1926 issue: 4 year: 2013 ident: 1213_CR15 publication-title: J. Virol. doi: 10.1128/JVI.02903-12 – volume: 348 start-page: 439 issue: 6233 year: 2015 ident: 1213_CR13 publication-title: Science doi: 10.1126/science.aaa4919 – volume: 17 start-page: e1008859 issue: 2 year: 2021 ident: 1213_CR11 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1008859 – volume: 17 start-page: e0011851 issue: 12 year: 2023 ident: 1213_CR12 publication-title: PLoS Negl. Trop. Dis. doi: 10.1371/journal.pntd.0011851 – volume: 70 start-page: 408 issue: 4 year: 2017 ident: 1213_CR8 publication-title: Jpn J. Infect. Dis. doi: 10.7883/yoken.JJID.2016.417 – volume: 8 start-page: e1002924 issue: 9 year: 2012 ident: 1213_CR2 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1002924 – volume: 207 start-page: 232 year: 2014 ident: 1213_CR17 publication-title: J. Virol. Methods doi: 10.1016/j.jviromet.2014.07.003 – volume: 88 start-page: 7317 issue: 13 year: 2014 ident: 1213_CR19 publication-title: J. Virol. doi: 10.1128/JVI.00512-14 – volume: 96 start-page: 6 issue: Pt 1 year: 2015 ident: 1213_CR7 publication-title: J. Gen. Virol. doi: 10.1099/vir.0.067108-0 – volume: 5 start-page: e529 issue: 6 year: 2024 ident: 1213_CR4 publication-title: Lancet Microbe doi: 10.1016/S2666-5247(24)00021-1 |
| SSID | ssj0000529419 |
| Score | 2.447236 |
| Snippet | The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information... Abstract The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 16285 |
| SubjectTerms | 631/250/590 692/699/255 Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Epidemics Fever Hemorrhagic fever Humanities and Social Sciences Hydrogen peroxide Immunization Infections Infectious diseases Inoculation Laboratory animals multidisciplinary Pathogens Plant viruses Proteins Rabbits Science Science (multidisciplinary) Serology Stomatitis Vaccines Vaccinia virus - genetics Vaccinia virus - immunology Veterinary medicine Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Vaccines - immunology Virology |
| SummonAdditionalLinks | – databaseName: Open Access Journals (DOAJ) dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiFIeaUtlJG4Q1bEdxz7SqlWFBCcq9WbZsb3sgQR1d1vBr2fGzi5dHuqFa-JEzszY801m_A0hb7TXPpkQat6ZUEvDU61Tl2ovMlzQITA8nPzxk7q4lB-u2qs7rb6wJqzQAxfBHUN8ITT4IcOCl44pb0wKplfKyd6FLjOBgs-7E0wVVm9uZGOmUzJM6OMFeCo8TcaxVo03or7d8kSZsP9vKPPPYsnfMqbZEZ0_IY8nBEnfl5nvkgdxeEoelp6S3_fIeLrpLEjHRAHfUQi7C0csXhjiKv_c-AEvpyDWuR-xkJC6mZsDVKQnbkEhRp6N9GZ-vVpQLIyfUfCf-POK3rgeM_H06xgQwMODz8jl-dnn04t66qpQ99LIZd0zhy2Gg8atBcCfUEoqHnvZ9QAOWkzFRNGnFjybb2NoY0oqqACxmkOuNy6ek51hHOJLQpV3MXU-6bbz0rPGOaMbp5mOnDdOqoq8XUvYfivkGTYnvYW2RR8W9GGzPuxtRU5QCZuRSHydL4A52Mkc7H3mUJHDtQrttBoXVnAmIFKDWKoirze3YR1hcsQNcVzlMRy-o5OmIi-KxjczkUzAPie7iugtW9ia6vadYf4lc3U3HDGeYBV5tzabX_P6tyz2_4csDsgjnu0duWYPyc7yehVfAYRa-qO8Wn4Cho0YgQ priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkLguWVUpCRuEFUx3Yc-4RoRVUhlRNFe4vs2F720KRsdlvRX8-Mk021vK52Ij9m7Pk8T0LeaqddNN7nvDI-l4bHXMcq5k4kuKC9ZxicfPZFnZ7Lz_NyPirc-tGtcnsnpovadw3qyA8FZwLQNuDhD5c_cqwahdbVsYTGXXIPU5chV1fzatKxoBVLFmaMlWFCH_YgrzCmjKPHGi9Efr0jj1La_r9hzT9dJn-zmyZxdPKIPBxxJP04EP4xuRPaGbk_VJb8OSOzb-jmkmJt6dloPn9CuuOp6iDtIgXsR-FJPuSPxYY2bJLi4waGpLDlS9ehkyG1C7sEGEmPbE_h_bzo6NVytekpOs0vKMhWVGzRK9vgMPSi8wju4cen5Pzk09fj03ysuJA30sh13jCL5Ye9xmsHgKFQSioeGlk1ABxKNNME0cQSpJ4rgy9DjMorD-84i3nguHhG9tquDS8IVc6GWLmoy8pJxwprjS6sZjpwXlipMvJuu-_15ZBYo04GcaHrgUo1UKlOVKqvM3KEpJm-xKTYqaFbLerxjNXwFBUaIIth3knLlDMmetMoZWVjfSUzcrAlbD2e1L6-5auMvJm64Yyh4cS2odukbziso5ImI88HPphmIpmAO1BWGdE7HLIz1d2edvk95fEuOOI_wTLyfstMt_P6917s_38ZL8kDnvgbM8wekL31ahNeAXBau9fpdPwCjMMXuA priority: 102 providerName: ProQuest |
| Title | Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities |
| URI | https://link.springer.com/article/10.1038/s41598-025-01213-w https://www.ncbi.nlm.nih.gov/pubmed/40348847 https://www.proquest.com/docview/3203960118 https://www.proquest.com/docview/3202857749 https://pubmed.ncbi.nlm.nih.gov/PMC12065830 https://doaj.org/article/1563821890db4a06b99fd9c66a4cad74 |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB71ISQuiDcpZWUkbhCR2I5jH3dXraqVqBBQaW-RHdvLHpqgfbSiv56xkyxaKAdOkRw7cjxjzzee8WeAd9JI45W1KS2VTbmiPpW-9KlhES5Ia7NwOPnTpbi44rN5MT8AOpyFiUn7kdIyLtNDdtjHNRqacBiMhlQzmrP09hCOA1U76vbxeDz7OtvtrITYFc9Vf0ImY_KexntWKJL134cw_06U_CNaGo3Q-WN41KNHMu76-wQOXPMUHnT3Sf58Bu10d6sgaT1BbEfQ5e74YUNB47ZxY-MOP05wSJemDUmERC_0EmEimeg1Qf940ZKb5Wq7JiEpfkHQdoaNK3Kj6xCFJ9etDeAdGz6Hq_Ozb9OLtL9RIa254pu0znS4XtjKsKwg8GNCcEFdzcsagUERwjCO1b5Aq2YKZwvnvbDCop-mA88bZS_gqGkb9wqIMNr50nhZlIabLNdayVzLTDpKc81FAu-HEa5-dMQZVQx4M1l18qhQHlWUR3WbwCQIYVczkF7Hgna1qHolqNDVZBIhicqs4ToTRilvVS2E5rW2JU_gdBBh1c_EdcVoxtBLQz8qgbe71ziHQmBEN67dxjoU_6PkKoGXncR3PeEZwzWOlwnIPV3Y6-r-m2b5PfJ05zTgO5Yl8GFQm9_9-vdYnPxf9dfwkEbNDoyyp3C0WW3dGwRKGzOCw3Jejvr5gc_J2eXnL1g6FdNR3Hz4BfxmFCs |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLaqIgQXBMPSQAEjwQmiOo6T2AeEaKGa0k5PLeot2LE9zIGkzNJR-VH8Rt5zkqmG7dZrFsXx277ntxHyUhppvLI25oWysVDcx9IXPjZpgAvSWobFyaPjfHgqPp1lZxvkZ18Lg2mVvU4Mito2FZ6R76ScpYC2AQ-_O_8e49QojK72IzRatjh0l0tw2WZvDz4AfV9xvv_xZG8Yd1MF4kooMY8rpnHErpUoWgB-0jwXOXeVKCowjhmGIlxa-Qw0u8mczZz3uc0t-Coae51howNQ-TfA8DJ09oqzYnWmg1EzkaiuNoelcmcG9hFr2DhmyPEkjZdr9i-MCfgbtv0zRfO3OG0wf_t3yZ0Ot9L3LaPdIxuuHpCb7STLywEZfMa0mlDbS0dduP4-afZWUw5p4ylgTTqpbduvFi_UbhEOWn7AJymQeGIaTGqkeqwnAFvprp5R8NfHDb2YTBczikn6Ywq2HA_S6IWu8DP0W2PRmYAXH5DTa6HFQ7JZN7XbIjQ32vnCeJkVRhiWaK1koiWTjvNEizwir_t9L8_bRh5lCMCnsmypVAKVykClchmRXSTN6klswh0uNNNx2cl0Ca5vKgEiKWaN0Cw3SnmrqjzXotK2EBHZ7glbdpphVl7xcURerG6DTGOgRteuWYRnOPxHIVREHrV8sFqJYCnoXFFERK5xyNpS1-_Uk6-hb3jCEW-mLCJvema6Wte_9-Lx_3_jObk1PBkdlUcHx4dPyG0eeB27226Tzfl04Z4CaJubZ0FSKPly3aL5CwAkUks |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9QwFLaqqUBcEAxboICR4ARRE9tJnANCTNtRS-moQhT1ltqxPcyBpMzSUflp_Drec5Kphu3WaxbF8du-57cR8lJqqV1uTMiy3IQiZy6ULnOh5h4uSGMiLE4-GqX7J-LDaXK6QX52tTCYVtnpRK-oTV3iGfk2ZxEHtA14eNu1aRHHu8N3599DnCCFkdZunEbDIof2cgnu2-ztwS7Q-hVjw73PO_thO2EgLEUu5mEZKRy3aySKGQAhnqYiZbYUWQmGMsGwhOWlS0DL68SaxDqXmtSA36Kw7xk2PQD1v5mhV9Qjm4O90fGn1QkPxtBEnLeVOhGX2zOwlljRxjBfjsU8XK5ZQz804G9I98-Ezd-itt4YDu-Q2y2Kpe8btrtLNmzVJzeauZaXfdL_gkk2vtKXHrXB-3uk3lnNPKS1o4A86aQyTfdavFDZhT92-QGfpEDwia4xxZGqsZoAiKUDNaPgvY9rejGZLmYUU_bHFCw7HqvRC1XiZ-i32qBrAS_eJyfXQo0HpFfVlX1EaKqVdZl2Msm00FGsVC5jJSNpGYuVSAPyutv34rxp61H4cDyXRUOlAqhUeCoVy4AMkDSrJ7Elt79QT8dFK-EFOMJcAmDKI6OFilKd587kZZoqUSqTiYBsdYQtWj0xK664OiAvVrdBwjFsoypbL_wzDP4jE3lAHjZ8sFqJiDhoYJEFRK5xyNpS1-9Uk6--i3jMEH3yKCBvOma6Wte_9-Lx_3_jObkJYll8PBgdPiG3mGd1bHW7RXrz6cI-BQQ3189aUaHk7Lql8xemm1fm |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+the+induction+of+neutralizing+antibodies+against+Bas+congo+virus+using+several+vaccine+modalities&rft.jtitle=Scientific+reports&rft.au=Park%2C+Eun-Sil&rft.au=Yoshikawa%2C+Tomoki&rft.au=Tani%2C+Hideki&rft.au=Kimura%2C+Masanobu&rft.date=2025-05-10&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=15&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-025-01213-w&rft.externalDocID=10_1038_s41598_025_01213_w |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |