Integration of Transcriptional Repression and Polycomb-Mediated Silencing of WUSCHEL in Floral Meristems

Arabidopsis ( ) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of ( ), which is essential for stem cell maintenance. At floral stage 6, is repressed by KNUCKLES (KNU), a repressor directly activated by AGAMOUS. KNU was suggested to repre...

Full description

Saved in:
Bibliographic Details
Published inThe Plant cell Vol. 31; no. 7; pp. 1488 - 1505
Main Authors Sun, Bo, Zhou, Yingying, Cai, Jie, Shang, Erlei, Yamaguchi, Nobutoshi, Xiao, Jun, Looi, Liang-Sheng, Wee, Wan-Yi, Gao, Xiuying, Wagner, Doris, Ito, Toshiro
Format Journal Article
LanguageEnglish
Published England American Society of Plant Biologists 01.07.2019
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Arabidopsis ( ) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of ( ), which is essential for stem cell maintenance. At floral stage 6, is repressed by KNUCKLES (KNU), a repressor directly activated by AGAMOUS. KNU was suggested to repress through histone deacetylation; however, how the changes in the chromatin state of are initiated and maintained to terminate the floral meristem remains elusive. Here, we show that KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of After KNU is induced, it binds to the promoter and causes eviction of SPLAYED, which is a known activator of and can oppose polycomb repression. KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of This multi-step silencing of leads to the termination of floral stem cells, ensuring proper carpel development. Thus, our work describes a detailed mechanism for heritable floral stem cell termination in a precise spatiotemporal manner.
AbstractList Arabidopsis (Arabidopsis thaliana) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of WUSCHEL (WUS), which is essential for stem cell maintenance. At floral stage 6, WUS is repressed by KNUCKLES (KNU), a repressor directly activated by AGAMOUS. KNU was suggested to repress WUS through histone deacetylation; however, how the changes in the chromatin state of WUS are initiated and maintained to terminate the floral meristem remains elusive. Here, we show that KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of WUS After KNU is induced, it binds to the WUS promoter and causes eviction of SPLAYED, which is a known activator of WUS and can oppose polycomb repression. KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of WUS This multi-step silencing of WUS leads to the termination of floral stem cells, ensuring proper carpel development. Thus, our work describes a detailed mechanism for heritable floral stem cell termination in a precise spatiotemporal manner.
The zinc-finger protein KNUCKLES integrates transcriptional repression with polycomb-mediated silencing of the floral stem cell determinant WUSCHEL. Arabidopsis ( Arabidopsis thaliana ) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of WUSCHEL ( WUS ), which is essential for stem cell maintenance. At floral stage 6, WUS is repressed by KNUCKLES (KNU), a repressor directly activated by AGAMOUS. KNU was suggested to repress WUS through histone deacetylation; however, how the changes in the chromatin state of WUS are initiated and maintained to terminate the floral meristem remains elusive. Here, we show that KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of WUS . After KNU is induced, it binds to the WUS promoter and causes eviction of SPLAYED, which is a known activator of WUS and can oppose polycomb repression. KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of WUS . This multi-step silencing of WUS leads to the termination of floral stem cells, ensuring proper carpel development. Thus, our work describes a detailed mechanism for heritable floral stem cell termination in a precise spatiotemporal manner.
Arabidopsis ( ) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of ( ), which is essential for stem cell maintenance. At floral stage 6, is repressed by KNUCKLES (KNU), a repressor directly activated by AGAMOUS. KNU was suggested to repress through histone deacetylation; however, how the changes in the chromatin state of are initiated and maintained to terminate the floral meristem remains elusive. Here, we show that KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of After KNU is induced, it binds to the promoter and causes eviction of SPLAYED, which is a known activator of and can oppose polycomb repression. KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of This multi-step silencing of leads to the termination of floral stem cells, ensuring proper carpel development. Thus, our work describes a detailed mechanism for heritable floral stem cell termination in a precise spatiotemporal manner.
Author Wagner, Doris
Sun, Bo
Xiao, Jun
Gao, Xiuying
Cai, Jie
Zhou, Yingying
Wee, Wan-Yi
Ito, Toshiro
Looi, Liang-Sheng
Yamaguchi, Nobutoshi
Shang, Erlei
Author_xml – sequence: 1
  givenname: Bo
  orcidid: 0000-0002-5548-3850
  surname: Sun
  fullname: Sun, Bo
  organization: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
– sequence: 2
  givenname: Yingying
  orcidid: 0000-0001-6623-3331
  surname: Zhou
  fullname: Zhou, Yingying
  organization: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
– sequence: 3
  givenname: Jie
  orcidid: 0000-0001-9763-4437
  surname: Cai
  fullname: Cai, Jie
  organization: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
– sequence: 4
  givenname: Erlei
  orcidid: 0000-0003-0551-9605
  surname: Shang
  fullname: Shang, Erlei
  organization: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
– sequence: 5
  givenname: Nobutoshi
  orcidid: 0000-0003-3738-6157
  surname: Yamaguchi
  fullname: Yamaguchi, Nobutoshi
  organization: Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama, 332-0012, Japan
– sequence: 6
  givenname: Jun
  orcidid: 0000-0002-6077-2155
  surname: Xiao
  fullname: Xiao, Jun
  organization: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084
– sequence: 7
  givenname: Liang-Sheng
  orcidid: 0000-0003-0751-3936
  surname: Looi
  fullname: Looi, Liang-Sheng
  organization: Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore
– sequence: 8
  givenname: Wan-Yi
  orcidid: 0000-0002-9616-2420
  surname: Wee
  fullname: Wee, Wan-Yi
  organization: Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore
– sequence: 9
  givenname: Xiuying
  orcidid: 0000-0001-9416-6498
  surname: Gao
  fullname: Gao, Xiuying
  organization: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
– sequence: 10
  givenname: Doris
  orcidid: 0000-0003-4656-2490
  surname: Wagner
  fullname: Wagner, Doris
  organization: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6084
– sequence: 11
  givenname: Toshiro
  orcidid: 0000-0002-8206-2787
  surname: Ito
  fullname: Ito, Toshiro
  email: itot@bs.naist.jp
  organization: Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31068455$$D View this record in MEDLINE/PubMed
BookMark eNpVUU1P3DAQtSoQsJRbz1WOHJplHMfe5IKEVlCQFoEKK7hZjj1eXCV2amcr7b9vtiwITjOa9zFPehOy54NHQr5RmFIK_Gzo9ZRWU4CSwxdyRDkr8qKunvfGHUrIS8HpIZmk9BsA6IzWB-SQURBVyfkRebnxA66iGlzwWbDZY1Q-6ej67UG12S_sI6a0RZU32X1oNzp0TX6LxqkBTfbgWvTa-dVW_bR8mF9fLjLns6s2xFF_i9GlAbv0lexb1SY82c1jsry6fJxf54u7nzfzi0Wuy7oc8sZaXoDQSllhGyMAea2oBUutBTHGNhoMU4UVla0aY6qZUYYVtUXAGULDjsn5q2-_bjo0Gv0w5pB9dJ2KGxmUk58R717kKvyVQjBeCTYanO4MYvizxjTIziWNbas8hnWSRcFoXVIxoyP1xytVx5BSRPv-hoLcliPHciSt5P9yRvr3j9HeyW9tsH-Dd5Ab
CitedBy_id crossref_primary_10_1016_j_envexpbot_2021_104664
crossref_primary_10_1146_annurev_genet_071719_020439
crossref_primary_10_1007_s42994_022_00093_2
crossref_primary_10_1016_j_tplants_2021_12_002
crossref_primary_10_1093_jxb_erac013
crossref_primary_10_1111_nph_18034
crossref_primary_10_1016_j_indcrop_2023_116240
crossref_primary_10_1016_j_xplc_2021_100273
crossref_primary_10_1186_s12870_022_03895_0
crossref_primary_10_1007_s00122_024_04578_0
crossref_primary_10_1073_pnas_2221181120
crossref_primary_10_3389_fpls_2021_704351
crossref_primary_10_1038_s41467_024_46941_1
crossref_primary_10_1038_s41598_020_76750_7
crossref_primary_10_3389_fevo_2019_00437
crossref_primary_10_1073_pnas_2102826118
crossref_primary_10_1134_S002689332102031X
crossref_primary_10_1016_j_ijbiomac_2024_129486
crossref_primary_10_1111_nph_18715
crossref_primary_10_3390_plants10061165
crossref_primary_10_1111_nph_18757
crossref_primary_10_3389_fevo_2020_00089
crossref_primary_10_1016_j_pbi_2021_102012
crossref_primary_10_1093_jxb_eraa065
crossref_primary_10_1016_j_xplc_2021_100267
crossref_primary_10_1093_plcell_koae123
crossref_primary_10_1007_s00299_020_02511_5
crossref_primary_10_3390_agronomy12123132
crossref_primary_10_3389_fpls_2020_600726
crossref_primary_10_3389_fpls_2021_805879
crossref_primary_10_1016_j_plantsci_2022_111201
crossref_primary_10_1242_dev_173377
crossref_primary_10_1371_journal_pgen_1011203
crossref_primary_10_1016_j_pbi_2021_102009
crossref_primary_10_1007_s00425_024_04357_7
crossref_primary_10_1093_plphys_kiad025
crossref_primary_10_1073_pnas_2216062120
crossref_primary_10_1093_plcell_koad123
crossref_primary_10_1093_plcell_koad246
crossref_primary_10_1093_plphys_kiad292
crossref_primary_10_3390_ijms24032401
crossref_primary_10_1007_s11103_021_01182_4
crossref_primary_10_1146_annurev_arplant_102820_093218
crossref_primary_10_3389_fpls_2021_635500
crossref_primary_10_1111_jipb_13351
crossref_primary_10_1007_s00122_023_04384_0
crossref_primary_10_1002_pld3_476
crossref_primary_10_1080_15592324_2019_1659706
crossref_primary_10_1093_plcell_koab139
crossref_primary_10_1111_tpj_15184
crossref_primary_10_1093_plphys_kiad441
crossref_primary_10_1016_j_jplph_2020_153142
crossref_primary_10_3389_fpls_2023_1323507
crossref_primary_10_1093_jxb_erab490
crossref_primary_10_3390_plants13030359
crossref_primary_10_3390_epigenomes6010008
crossref_primary_10_1111_tpj_16637
crossref_primary_10_1016_j_plaphy_2022_06_026
crossref_primary_10_1242_dev_200120
crossref_primary_10_1007_s00299_022_02864_z
crossref_primary_10_1038_s41477_023_01575_x
crossref_primary_10_3390_plants12091879
ContentType Journal Article
Copyright 2019 American Society of Plant Biologists. All rights reserved.
2019 American Society of Plant Biologists. All rights reserved. 2019
Copyright_xml – notice: 2019 American Society of Plant Biologists. All rights reserved.
– notice: 2019 American Society of Plant Biologists. All rights reserved. 2019
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1105/tpc.18.00450
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Botany
EISSN 1532-298X
EndPage 1505
ExternalDocumentID 10_1105_tpc_18_00450
31068455
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Fundamental Research Funds for the Central Universities and
– fundername: Grant-in-Aid for Challenging Exploratory Research
  grantid: 15K14549; 18K19342
– fundername: NAIST Foundation
– fundername: Temasek Life Sciences Laboratory
– fundername: ;
  grantid: 31670308
– fundername: National Research Foundation Singapore
  grantid: NRFCRP001-108
– fundername: Grant-in-Aid for Scientific Research on Innovative Areas
  grantid: 15H01234; 15H01356; 17H05843; 18H04839
– fundername: Grant-in-Aid for Scientific Research A
  grantid: 15H02405
GroupedDBID ---
-DZ
-~X
0R~
123
29O
2AX
2FS
2WC
2~F
3V.
4.4
53G
5VS
5WD
7X2
7X7
85S
88A
88E
88I
8AF
8AO
8CJ
8FE
8FH
8FI
8FJ
8FW
8R4
8R5
AAHBH
AAHKG
AAPXW
AARHZ
AAUAY
AAVAP
AAWDT
AAXTN
AAYJJ
ABBHK
ABEJV
ABJNI
ABMNT
ABPLY
ABPPZ
ABPTD
ABTLG
ABUWG
ABXSQ
ABXVV
ACBTR
ACFRR
ACGFO
ACGOD
ACIPB
ACIWK
ACNCT
ACPRK
ACUFI
ACUTJ
ACZBC
ADACV
ADBBV
ADIPN
ADIYS
ADQBN
ADULT
ADVEK
ADYHW
AEEJZ
AENEX
AEUPB
AFAZZ
AFFDN
AFFNX
AFFZL
AFGWE
AFKRA
AFRAH
AFYAG
AGCDD
AGMDO
AGUYK
AHMBA
AHXOZ
AICQM
AJEEA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ANFBD
AQDSO
AQVQM
AS~
ATCPS
ATGXG
AZQEC
BAWUL
BBNVY
BCRHZ
BENPR
BEYMZ
BHPHI
BPHCQ
BTFSW
BVXVI
C1A
CBGCD
CCPQU
CGR
CS3
CUY
CVF
D1J
DATOO
DIK
DOOOF
DU5
DWQXO
E3Z
EBS
ECGQY
ECM
EIF
EJD
F5P
F8P
F9R
FLUFQ
FOEOM
FRP
FYUFA
GNUQQ
GTFYD
GX1
H13
HCIFZ
HGD
HMCUK
HTVGU
H~9
IPSME
ISR
JAAYA
JBMMH
JBS
JENOY
JHFFW
JKQEH
JLS
JLXEF
JPM
JSODD
JST
KOP
KQ8
KSI
KSN
LK8
M0K
M0L
M1P
M2P
M2Q
M7P
MV1
MVM
N9A
NEJ
NOMLY
NPM
OBOKY
OJZSN
OK1
OWPYF
P0-
P2P
PQQKQ
PROAC
PSQYO
Q2X
RHF
RHI
ROX
RPB
RPM
RWL
RXW
S0X
SA0
TAE
TCN
TN5
TR2
U5U
UBC
UKHRP
UKR
VQA
W8F
WH7
WHG
WOQ
XOL
XSW
Y6R
YBU
YR2
YSK
ZCA
ZCG
ZCN
~KM
AAYXX
CITATION
7X8
5PM
AASNB
ID FETCH-LOGICAL-c494t-bff5206caaf6fbd60e59a1f0f1ff06106dc0d3a2f68f8bdd87dad329fe0e7e0b3
ISSN 1040-4651
IngestDate Tue Sep 17 21:02:11 EDT 2024
Wed Dec 04 15:58:31 EST 2024
Fri Dec 06 04:17:22 EST 2024
Sat Nov 02 12:26:41 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
License 2019 American Society of Plant Biologists. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c494t-bff5206caaf6fbd60e59a1f0f1ff06106dc0d3a2f68f8bdd87dad329fe0e7e0b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantcell.org) are: Bo Sun (sunbo@nju.edu.cn) and Toshiro Ito (itot@bs.naist.jp).
Current address: State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
www.plantcell.org/cgi/doi/10.1105/tpc.18.00450
ORCID 0000-0001-9416-6498
0000-0002-5548-3850
0000-0001-9763-4437
0000-0002-8206-2787
0000-0003-0751-3936
0000-0003-0551-9605
0000-0003-4656-2490
0000-0003-3738-6157
0000-0002-9616-2420
0000-0001-6623-3331
0000-0002-6077-2155
OpenAccessLink http://www.plantcell.org/content/plantcell/31/7/1488.full.pdf
PMID 31068455
PQID 2231941671
PQPubID 23479
PageCount 18
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6635863
proquest_miscellaneous_2231941671
crossref_primary_10_1105_tpc_18_00450
pubmed_primary_31068455
PublicationCentury 2000
PublicationDate 2019-07-01
PublicationDateYYYYMMDD 2019-07-01
PublicationDate_xml – month: 07
  year: 2019
  text: 2019-07-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle The Plant cell
PublicationTitleAlternate Plant Cell
PublicationYear 2019
Publisher American Society of Plant Biologists
Publisher_xml – name: American Society of Plant Biologists
SSID ssj0001719
Score 2.588633
Snippet Arabidopsis ( ) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of ( ), which is essential for...
Arabidopsis (Arabidopsis thaliana) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of WUSCHEL...
The zinc-finger protein KNUCKLES integrates transcriptional repression with polycomb-mediated silencing of the floral stem cell determinant WUSCHEL....
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 1488
SubjectTerms Arabidopsis - genetics
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Carrier Proteins - genetics
Carrier Proteins - metabolism
Chromatin - metabolism
Epigenesis, Genetic
Epistasis, Genetic
Flowers - genetics
Gene Expression Regulation, Plant
Gene Silencing
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Meristem - genetics
Models, Biological
Polycomb-Group Proteins - metabolism
Promoter Regions, Genetic - genetics
Protein Binding
Repressor Proteins - metabolism
Transcription, Genetic
Title Integration of Transcriptional Repression and Polycomb-Mediated Silencing of WUSCHEL in Floral Meristems
URI https://www.ncbi.nlm.nih.gov/pubmed/31068455
https://search.proquest.com/docview/2231941671
https://pubmed.ncbi.nlm.nih.gov/PMC6635863
Volume 31
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKQIKXCQaMjg8ZCZ5Qhh0njvMIVacyKAJtFXuLYsfWgqpkGulD99dzdj7b9WHwElVp7Ca-X893l7vfIfQu1lGqhJ96TDLjBWFqPKmY9CJNFaUZF0Tbeuf5dz5bBKcX4cVodDOsLqnksbrZWVfyP1KFcyBXWyX7D5LtJoUT8BnkC0eQMBzvJOMvDddDY_S5fafVAo40v8lyrROOf5TLNdyF9OauPYe1NHNbctTkPf9anE1m0282AHKydHX7c0fj3PKZ_-5xZTsdVR9szL9_p1S3fS_7QHS5cuodZl-326N71-HSB07zDlBnbch6er3U-TAK4Qqf2ihErThtZqLtq17vK60y9T0_dq2DO23L6ABV0UB1gl8mBtswGKrhbhVPLBtGdaWOqU2DDWre2k0m7a0drss7dB4PCRMYnVCRuNH30H1Lomj7Lnz92TPN08g1hemeqyuaCD8Of3vTnLnlo2yn2g5sl_PHaL9xOvCnGkFP0EgXB-jB5xIcg_UBejhpm_49RZcDSOHS4C1I4R5SGCCFb0EKd5CyoxtI4bzANaRwB6lnaHEyPZ_MvKYZh6eCOKg8aUzoE67S1HAjM050GKfUEEONAZuQ8EyRjKW-4cIImWUiytKM-bHRREeaSPYc7RVloV8gTJiJlS-kSg3450wJW_nnBxHPqNI8pmP0vl3T5KrmXEl2SW6M3rYLnsAyWdSnhS5XfxKweWkMrkYEcx3WAuhmAn-GiyAMxyjaEE13gSVc3_ymyC8d8bq1zgVnR3e8v5foUf9XeYX2quuVfg0mbCXfOKz9BWZan6E
link.rule.ids 230,314,780,784,885,27924,27925
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integration+of+Transcriptional+Repression+and+Polycomb-Mediated+Silencing+of+WUSCHEL+in+Floral+Meristems&rft.jtitle=The+Plant+cell&rft.au=Sun%2C+Bo&rft.au=Zhou%2C+Yingying&rft.au=Cai%2C+Jie&rft.au=Shang%2C+Erlei&rft.date=2019-07-01&rft.issn=1040-4651&rft.eissn=1532-298X&rft.volume=31&rft.issue=7&rft.spage=1488&rft.epage=1505&rft_id=info:doi/10.1105%2Ftpc.18.00450&rft.externalDBID=n%2Fa&rft.externalDocID=10_1105_tpc_18_00450
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1040-4651&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1040-4651&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1040-4651&client=summon