Comparative performance and health economic analysis of prenatal screening for down syndrome in Fujian province, China

• Published in: Scientific reports Vol. 15; no. 1; pp. 23940 - 10
• Main Authors: Zheng, Lin, Yin, Nuolan, Wang, Meiying, Huang, Hailong, Zhang, Shuyu, Su, Linjuan, Xu, Liangpu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/700/139; 692/700/1538; 692/700/228; 692/700/3934; 692/700/459; 692/700/478; Adult; Age; Birth defects; Cell culture; Childrens health; China - epidemiology; Clinical medicine; Cost analysis; Cost-Benefit Analysis; Cost-effectiveness analysis; Down syndrome; Down Syndrome - diagnosis; Down Syndrome - economics; Down Syndrome - epidemiology; Down's syndrome; Economic analysis; Economics; Female; Fetuses; First-trimester serological screening; Health economics; Humanities and Social Sciences; Humans; multidisciplinary; Noninvasive prenatal test; Noninvasive Prenatal Testing - economics; Noninvasive Prenatal Testing - methods; Pregnancy; Pregnancy Trimester, First; Prenatal diagnosis; Prenatal Diagnosis - economics; Prenatal Diagnosis - methods; Prenatal screening; Retrospective Studies; Science; Science (multidisciplinary); Sensitivity analysis; Sensitivity and Specificity; Sex chromosomes; Trisomy; Trisomy 18 Syndrome - diagnosis; Womens health; China; Cost-effectiveness analysis; Prenatal screening; Noninvasive prenatal test; Down syndrome; First-trimester serological screening

To compare the performance of first-trimester serum screening (FTSS) and non-invasive prenatal testing (NIPT) in detecting fetal chromosomal aneuploidies trisomy 21 (T21) and trisomy 18 (T18), and to evaluate the cost-effectiveness and clinical feasibility of four screening strategies for the preven...