Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming

• Published in: Oncogenesis (New York, NY) Vol. 14; no. 1; pp. 6 - 13
• Main Authors: Wang, Ssu-Han, Chen, Yu-Lin, Huang, Shih-Han, Fu, Yu-Ke, Lin, Su-Fang, Jiang, Shih Sheng, Liu, Shu-Chen, Hsiao, Jenn-Ren, Chang, Jang-Yang, Chen, Ya-Wen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.03.2025; Nature Publishing Group
• Subjects: 13/1; 13/105; 13/21; 13/51; 38/39; 38/90; 42/109; 631/443/319; 631/67/1536; 631/67/2327; 631/67/327; 631/80/84; 64/60; Actin; Apoptosis; Cancer; CD11a antigen; Cell Biology; Fibroblast activation protein; Fibroblasts; Gene expression; Glucose metabolism; Glycolysis; Human Genetics; Immunohistochemistry; Internal Medicine; Lactic acid; Leukocyte migration; LFA-1 antigen; Lymphocytes; Medicine; Medicine & Public Health; Metastases; Oncology; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Smooth muscle; Squamous cell carcinoma; Tumor microenvironment; Tumors; Vimentin

Cancer-associated fibroblast (CAF) recruitment and activation within the tumor microenvironment (TME) are increasingly acknowledged as drivers of oral squamous cell carcinoma (OSCC) tumor growth and metastasis. Therefore, the mechanisms underlying tumor cell and fibroblast crosstalk warrant further...