Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 36; no. 10; pp. 2009 - 2017
• Main Authors: CHAI, Xiaoqian J, WHITFIELD-GABRIELI, Susan, SHINN, Ann K, DE GABRIELI, John, NIETO CASTANON, Alfonso, MCCARTHY, Julie M, COHEN, Bruce M, ÖNGÜR, Dost
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.09.2011
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - physiopathology; Bipolar Disorder - psychology; Bipolar disorders; Brain research; Cerebral Cortex - physiopathology; Cohort Studies; Female; Humans; Magnetic Resonance Imaging - methods; Male; Medical sciences; Mood disorders; Neural Pathways - physiopathology; Original; Prefrontal Cortex - physiopathology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Rest - physiology; Rest - psychology; Schizophrenia; Schizophrenia - physiopathology; United States > US; Massachusetts; Mood disorder; DLPFC; Central nervous system; Schizophrenia; VLPFC; Bipolar disorder; Prefrontal cortex; insula; Nuclear magnetic resonance imaging; Encephalon; Psychosis; Dorsolateral prefrontal cortex; Medial prefrontal cortex; fMRI; Rest; functional connectivity; anticorrelations; Functional magnetic resonance imaging; Insular cortex; Functional imaging
• ISSN: 0893-133X; 1740-634X
• DOI: 10.1038/npp.2011.88

Bipolar disorder and schizophrenia overlap in symptoms and may share some underlying neural substrates. The medial prefrontal cortex (MPFC) may have a crucial role in the psychophysiology of both these disorders. In this study, we examined the functional connectivity between MPFC and other brain regions in bipolar disorder and schizophrenia using resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data were collected from 14 patients with bipolar disorder, 16 patients with schizophrenia, and 15 healthy control subjects. Functional connectivity maps from the MPFC were computed for each subject and compared across the three groups. The three groups showed distinctive patterns of functional connectivity between MPFC and anterior insula, and between MPFC and ventral lateral prefrontal cortex (VLPFC). The bipolar disorder group exhibited positive correlations between MPFC and insula, and between MPFC and VLPFC, whereas the control group exhibited anticorrelations between these regions. The schizophrenia group did not exhibit any resting-state correlation or anticorrelation between the MPFC and the VLPFC or insula. In contrast, neither patient group exhibited the significant anticorrelation between dorsal lateral prefrontal cortex (DLPFC) and MPFC that was exhibited by the control group. The decoupling of DLPFC with MPFC in bipolar disorder and schizophrenia is consistent with the impaired executive functioning seen in these disorders. Functional connectivity between MPFC and insula/VLPFC distinguished bipolar disorder from schizophrenia, and may reflect differences in the affective disturbances typical of each illness.