Self-propagating wave drives morphogenesis of skull bones in vivo

• Published in: Nature communications Vol. 16; no. 1; pp. 4330 - 11
• Main Authors: Dang, Yiteng, Lattner, Johanna, Lahola-Chomiak, Adrian A., Afonso, Diana Alves, Ulbricht, Elke, Taubenberger, Anna, Rulands, Steffen, Tabler, Jacqueline M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.05.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/51; 14; 14/19; 14/69; 631/136/1660; 631/136/818; 631/57/343/1361; 64; 64/60; Animals; Bones; Cell Differentiation; Cell fate; Cell migration; Cell Movement - physiology; Collagen - metabolism; Feedback; Humanities and Social Sciences; Material properties; Mechanical properties; Mice; Morphogenesis; Morphogenesis - physiology; multidisciplinary; Neuroimaging; Organogenesis; Osteoblasts - cytology; Osteoblasts - metabolism; Osteoblasts - physiology; Osteogenesis; Science; Science (multidisciplinary); Self propagation; Skull; Skull - cytology; Skull - embryology; Wave propagation

Cellular motion is a key feature of tissue morphogenesis and is often driven by migration. However, migration need not explain cell motion in contexts where there is little free space or no obvious substrate, such as those found during organogenesis of mesenchymal organs including the embryonic skul...