IL-33 accelerates cutaneous wound healing involved in upregulation of alternatively activated macrophages

• Published in: Molecular immunology Vol. 56; no. 4; pp. 347 - 353
• Main Authors: Yin, Hui, Li, Xiangyong, Hu, Shilian, Liu, Tao, Yuan, Baohong, Gu, Hongbiao, Ni, Qian, Zhang, Xiaofan, Zheng, Fang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2013
• Subjects: Alternatively activated macrophages; Animals; Antigens, Differentiation - metabolism; collagen; Collagen - genetics; Collagen - metabolism; Cytokines; extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; fibronectins; Fibronectins - genetics; Fibronectins - metabolism; Gene Expression - drug effects; gene expression regulation; genes; homeostasis; IL-33; immune response; Immunohistochemistry; Inflammation; Injections, Intraperitoneal; interleukin-1; Interleukin-33; Interleukins - genetics; Interleukins - metabolism; Interleukins - pharmacology; Lectins, C-Type - metabolism; Macrophage Activation - drug effects; macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; Mannose-Binding Lectins - metabolism; messenger RNA; Mice; Mice, Inbred BALB C; Receptors, Cell Surface - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin - drug effects; Skin - metabolism; Skin - physiopathology; Time Factors; tissue repair; Up-Regulation - drug effects; Wound healing; Wound Healing - drug effects; Inflammation; Wound healing; Cytokines; IL-33; Alternatively activated macrophages

•We examined the role of IL-33 in mucosal healing and epithelial restoration and repair.•The expression of IL-33 is enhanced in incisional wound skin.•Administration of exogenous IL-33 accelerates wound healing.•IL-33 promotes collagen deposition and ECM synthesis.•The effect of IL-33 is associated...