A programmable magnetic digital microfluidic platform integrated with electrochemical detection system
Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite...
Saved in:
| Published in | Microsystems & nanoengineering Vol. 11; no. 1; pp. 82 - 12 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
12.05.2025
Springer Nature B.V Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS
2
@CeO
2
/PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01–0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM
−1
·cm
−2
), and excellent recovery rate (88.1–113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing. |
|---|---|
| AbstractList | Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS
2
@CeO
2
/PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01–0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM
−1
·cm
−2
), and excellent recovery rate (88.1–113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing. Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS @CeO /PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01-0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM ·cm ), and excellent recovery rate (88.1-113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing. Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS2@CeO2/PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01-0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM-1·cm-2), and excellent recovery rate (88.1-113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing.Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS2@CeO2/PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01-0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM-1·cm-2), and excellent recovery rate (88.1-113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing. Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS2@CeO2/PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01–0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM−1·cm−2), and excellent recovery rate (88.1–113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing. Abstract Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets. However, most DMF systems usually rely on complex electrode fabrication and high driving voltages. Sensor integration in DMF systems is also quite rare. In this study, a programmable magnetic digital microfluidic (PMDMF) platform integrated with electrochemical detection system was proposed. It enables non-contact, flexible droplet manipulation without complex processes and high voltages, meeting the requirements of automated electrochemical detection. The platform includes a magnetic control system, a microfluidic chip, and an electrochemical detection system. The magnetic control system consists of a microcoil array circuit board, a N52 permanent magnet, and an Arduino control module. N52 magnets generate localized magnetic fields to drive droplet movement, while the Arduino module enables programmable control for precise manipulation. The maximum average velocity of the droplet is about 3.9 cm/s. The microfluidic chip was fabricated using 3D printing and the superhydrophobic surface of chip was fabricated by spray coating. The electrochemical detection system consists of the MoS2@CeO2/PVA working electrode, Ag/AgCl reference electrode, and carbon counter electrode. To evaluate the practical value of the integrated platform, glucose in sweat was automatically and accurately detected. The proposed platform has a wide linear detection range (0.01–0.25 mM), a lower LOD (6.5 μM), a superior sensitivity (7833.54 μA·mM−1·cm−2), and excellent recovery rate (88.1–113.5%). It has an extensive potential for future application in the fields of medical diagnostics and point-of-care testing. |
| ArticleNumber | 82 |
| Author | Feng, Shilun Jiang, Shuyue Zhao, Yong Wang, Lihua Zhao, Jianlong Cai, Gaozhe |
| Author_xml | – sequence: 1 givenname: Yong surname: Zhao fullname: Zhao, Yong organization: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, School of Graduate Study, University of Chinese Academy of Sciences – sequence: 2 givenname: Shuyue surname: Jiang fullname: Jiang, Shuyue organization: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, 2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences – sequence: 3 givenname: Gaozhe surname: Cai fullname: Cai, Gaozhe email: caigaozhe@shu.edu.cn organization: School of Microelectronics, Shanghai University – sequence: 4 givenname: Lihua surname: Wang fullname: Wang, Lihua email: wanglihua@shu.edu.cn organization: Institute of Materiobiology, College of Science, Shanghai University – sequence: 5 givenname: Jianlong surname: Zhao fullname: Zhao, Jianlong organization: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai Frontier Innovation Research Institute – sequence: 6 givenname: Shilun orcidid: 0000-0002-2560-2417 surname: Feng fullname: Feng, Shilun email: shilun.feng@mail.sim.ac.cn organization: State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40355456$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktv1TAQhSNUREvpH2CBIrFhExg_8vAKVRXQSpXYwNpy7Emurxz7YvtS9d_j25Q-WLCyNf7O8dhzXldHPnisqrcEPhJgw6fECeuHBmjbAAjCm-5FdUKhbZueM370ZH9cnaW0BQDSs15A-6o65sDalrfdSTWd17sY5qiWRY0O60XNHrPVtbGzzcrVi9UxTG5vTSnunMpTiEttfcYiymjqG5s3NTrUOQa9wcIXlcFcCjb4Ot2mjMub6uWkXMKz-_W0-vn1y4-Ly-b6-7eri_PrRnPBczMSI4hRqtMMe6oJ5QhCd0a0ehKaUq5gZEDYqDVjVE9U84m1nAwCiRpHxU6rq9XXBLWVu2gXFW9lUFbeFUKcpYrleQ6loD2fCKGqF4YPqMeJ91wP3ahFP5DRFK_Pq9duPy5oNPoclXtm-vzE242cw29JKHSiG9ri8OHeIYZfe0xZLjZpdE55DPskGQXGgA-DKOj7f9Bt2Edf_upAcQBW5l2od09beujl7zwLQFegDC2liNMDQkAeciPX3MiSG3mXG3kQsVWUCuxnjI93_0f1B4Q_xv8 |
| Cites_doi | 10.1002/elps.202100088 10.1039/C5LC00462D 10.1038/s41378-022-00475-y 10.1038/nature05058 10.1021/acssensors.9b01286 10.1016/j.bios.2021.113684 10.1093/nsr/nwac164 10.1039/C4CS00369A 10.1016/j.sna.2016.04.004 10.1007/s10404-007-0161-8 10.1039/C7LC00006E 10.1039/D3RA01817B 10.1039/D2LC01153K 10.3390/bios12050324 10.1016/j.aca.2024.342398 10.1002/pat.3190 10.1038/s41467-021-27879-0 10.1002/adma.200802244 10.1371/journal.pone.0238581 10.1021/acsami.2c20543 10.1016/j.heliyon.2023.e23721 10.1021/acssensors.4c01248 10.1039/D0CS00268B 10.1002/adma.201300383 10.1021/acs.langmuir.1c00329 10.1021/acs.analchem.8b05375 10.1038/s43586-022-00109-7 10.1039/D2LC00756H 10.1016/j.aca.2023.341077 10.1021/acsami.0c08179 10.1016/j.mtchem.2023.101638 10.1021/acssensors.0c02446 10.1038/s41586-022-05408-3 10.1126/sciadv.aay5808 10.1039/C9LC01126A 10.1038/s41467-021-27503-1 10.1021/acsami.6b09017 10.3390/bios10110166 10.1146/annurev-anchem-062011-143028 10.1021/acssensors.9b01057 10.1039/C7LC00025A 10.1038/s41378-021-00276-9 10.1039/D2MA00819J 10.1021/acsnano.3c07360 10.1016/j.bios.2018.08.061 10.1016/j.snb.2005.12.053 10.1126/science.1165719 10.1039/b819818g 10.1016/j.foodchem.2022.133630 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2025 2025. The Author(s). Copyright Springer Nature B.V. 2025 The Author(s) 2025 2025 |
| Copyright_xml | – notice: The Author(s) 2025 – notice: 2025. The Author(s). – notice: Copyright Springer Nature B.V. 2025 – notice: The Author(s) 2025 2025 |
| DBID | C6C AAYXX CITATION NPM 3V. 7X7 7XB 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AFKRA AZQEC BBNVY BENPR BGLVJ BHPHI CCPQU COVID DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. L6V LK8 M0S M7P M7S PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS PTHSS 7X8 5PM DOA |
| DOI | 10.1038/s41378-025-00914-6 |
| DatabaseName | Springer Nature OA/Free Journals CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection ProQuest One Community College Coronavirus Research Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Engineering Collection ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Biological Science Database Engineering Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student Technology Collection ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Engineering Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) Engineering Collection Engineering Database ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Materials Science & Engineering Collection ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 2055-7434 |
| EndPage | 12 |
| ExternalDocumentID | oai_doaj_org_article_9274f112a79d48ecbf474c86bc9781bd PMC12069685 40355456 10_1038_s41378_025_00914_6 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 62401555 funderid: https://doi.org/10.13039/501100001809 – fundername: Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) grantid: XTCX-KJ-2024-038 funderid: https://doi.org/10.13039/501100003399 – fundername: The equipment research and development projects of the Chinese Academy of Sciences (PTYQ2024YZ0010) – fundername: Postdoctoral Fellowship Program of CPSF under Grant Number GZC20232838 – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 62401555 – fundername: Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) grantid: XTCX-KJ-2024-038 |
| GroupedDBID | 0R~ 5VS 7X7 8FE 8FG 8FH 8FI 8FJ AAJSJ AASML ABJCF ABUWG ACGFS ADBBV ADMLS AFKRA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS ARCSS BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU EBLON EBS FYUFA GROUPED_DOAJ HCIFZ HMCUK HYE HZ~ KQ8 L6V LK8 M7P M7S M~E NAO O9- OK1 PHGZM PHGZT PIMPY PQQKQ PROAC PTHSS RNT RPM SNYQT UKHRP AAYXX CITATION NPM PQGLB 3V. 7XB 8FK AARCD AZQEC COVID DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c494t-b1d91daa6c3e72c124e09c6d95cf9c224a0b3013bcc332cf2c4f354189e1abba3 |
| IEDL.DBID | 7X7 |
| ISSN | 2055-7434 2096-1030 |
| IngestDate | Wed Aug 27 01:24:31 EDT 2025 Thu Aug 21 18:26:43 EDT 2025 Fri Jul 11 18:03:18 EDT 2025 Wed Aug 13 04:12:04 EDT 2025 Mon Jul 21 06:02:47 EDT 2025 Sun Jul 06 05:09:48 EDT 2025 Tue May 13 01:10:40 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2025. The Author(s). Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c494t-b1d91daa6c3e72c124e09c6d95cf9c224a0b3013bcc332cf2c4f354189e1abba3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-2560-2417 |
| OpenAccessLink | https://www.proquest.com/docview/3204003413?pq-origsite=%requestingapplication% |
| PMID | 40355456 |
| PQID | 3204003413 |
| PQPubID | 2041946 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_9274f112a79d48ecbf474c86bc9781bd pubmedcentral_primary_oai_pubmedcentral_nih_gov_12069685 proquest_miscellaneous_3203304889 proquest_journals_3204003413 pubmed_primary_40355456 crossref_primary_10_1038_s41378_025_00914_6 springer_journals_10_1038_s41378_025_00914_6 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-05-12 |
| PublicationDateYYYYMMDD | 2025-05-12 |
| PublicationDate_xml | – month: 05 year: 2025 text: 2025-05-12 day: 12 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Microsystems & nanoengineering |
| PublicationTitleAbbrev | Microsyst Nanoeng |
| PublicationTitleAlternate | Microsyst Nanoeng |
| PublicationYear | 2025 |
| Publisher | Nature Publishing Group UK Springer Nature B.V Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Springer Nature B.V – name: Nature Publishing Group |
| References | A Li (914_CR9) 2020; 6 E Sardini (914_CR34) 2020; 10 Y Zhang (914_CR17) 2017; 17 X Wu (914_CR42) 2023; 13 X Xu (914_CR13) 2023; 23 X Li (914_CR24) 2020; 12 B Yang (914_CR31) 2023; 23 DG Rackus (914_CR36) 2015; 44 Z Liao (914_CR37) 2018; 121 I Frozanpoor (914_CR4) 2021; 37 S Jiang (914_CR45) 2023; 32 S Kalsi (914_CR16) 2015; 15 HS Lin (914_CR19) 2022; 611 S Hu (914_CR29) 2022; 12 K Choi (914_CR14) 2012; 5 P Kanitthamniyom (914_CR33) 2021; 7 R Malinowski (914_CR41) 2020; 49 B Fall (914_CR46) 2023; 5 K Seo (914_CR26) 2013; 24 KP Sharma (914_CR49) 2024; 10 F Wang (914_CR12) 2023; 10 H Cheng (914_CR8) 2021; 42 T Kremers (914_CR43) 2020; 15 PH Lu (914_CR22) 2020; 20 E Huang (914_CR20) 2021; 195 C Son (914_CR27) 2023; 17 H Wang (914_CR47) 2022; 396 Y Zhang (914_CR44) 2013; 25 AR Wheeler (914_CR7) 2008; 322 Z Long (914_CR40) 2009; 9 H Geng (914_CR6) 2017; 17 BV Dang (914_CR2) 2019; 4 U Lehmann (914_CR23) 2006; 117 J Hartmann (914_CR5) 2022; 13 J Zhang (914_CR21) 2021; 12 J Wang (914_CR50) 2022; 3 QF Li (914_CR48) 2023; 15 R Vinoth (914_CR38) 2021; 6 GM Whitesides (914_CR1) 2006; 442 P Giménez-Gómez (914_CR35) 2019; 4 RPS de Campos (914_CR39) 2019; 91 J Rufo (914_CR11) 2022; 2 GY Huang (914_CR10) 2017; 9 RB Fair (914_CR3) 2007; 3 M Abdelgawad (914_CR15) 2009; 21 DS Rocha (914_CR32) 2023; 1254 Y Zeng (914_CR28) 2024; 1298 X Hu (914_CR18) 2023; 9 S Li (914_CR30) 2024; 9 SK Saroj (914_CR25) 2016; 244 |
| References_xml | – volume: 42 start-page: 2329 year: 2021 ident: 914_CR8 publication-title: Electrophoresis doi: 10.1002/elps.202100088 – volume: 15 start-page: 3065 year: 2015 ident: 914_CR16 publication-title: Lab Chip doi: 10.1039/C5LC00462D – volume: 9 start-page: 10 year: 2023 ident: 914_CR18 publication-title: Microsyst. Nanoeng. doi: 10.1038/s41378-022-00475-y – volume: 442 start-page: 368 year: 2006 ident: 914_CR1 publication-title: Nature doi: 10.1038/nature05058 – volume: 4 start-page: 3156 year: 2019 ident: 914_CR35 publication-title: ACS Sens. doi: 10.1021/acssensors.9b01286 – volume: 195 start-page: 113684 year: 2021 ident: 914_CR20 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2021.113684 – volume: 10 start-page: nwac164 year: 2023 ident: 914_CR12 publication-title: Natl Sci. Rev. doi: 10.1093/nsr/nwac164 – volume: 44 start-page: 5320 year: 2015 ident: 914_CR36 publication-title: Chem. Soc. Rev. doi: 10.1039/C4CS00369A – volume: 244 start-page: 112 year: 2016 ident: 914_CR25 publication-title: Sens. Actuat A-Phys. doi: 10.1016/j.sna.2016.04.004 – volume: 3 start-page: 245 year: 2007 ident: 914_CR3 publication-title: Microfluidics Nanofluidics doi: 10.1007/s10404-007-0161-8 – volume: 17 start-page: 1060 year: 2017 ident: 914_CR6 publication-title: Lab Chip doi: 10.1039/C7LC00006E – volume: 13 start-page: 16815 year: 2023 ident: 914_CR42 publication-title: Rsc Adv. doi: 10.1039/D3RA01817B – volume: 23 start-page: 785 year: 2023 ident: 914_CR31 publication-title: Lab chip doi: 10.1039/D2LC01153K – volume: 12 start-page: 324 year: 2022 ident: 914_CR29 publication-title: Biosensors doi: 10.3390/bios12050324 – volume: 1298 start-page: 342398 year: 2024 ident: 914_CR28 publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2024.342398 – volume: 24 start-page: 1075 year: 2013 ident: 914_CR26 publication-title: Polym. Advan. Technol. doi: 10.1002/pat.3190 – volume: 13 year: 2022 ident: 914_CR5 publication-title: Nat. Commun. doi: 10.1038/s41467-021-27879-0 – volume: 21 start-page: 920 year: 2009 ident: 914_CR15 publication-title: Adv. Mater. doi: 10.1002/adma.200802244 – volume: 15 start-page: e0238581 year: 2020 ident: 914_CR43 publication-title: PLoS One doi: 10.1371/journal.pone.0238581 – volume: 15 start-page: 13290 year: 2023 ident: 914_CR48 publication-title: ACS Appl Mater. Interfaces doi: 10.1021/acsami.2c20543 – volume: 10 year: 2024 ident: 914_CR49 publication-title: Heliyon doi: 10.1016/j.heliyon.2023.e23721 – volume: 9 start-page: 4256 year: 2024 ident: 914_CR30 publication-title: ACS Sens. doi: 10.1021/acssensors.4c01248 – volume: 49 start-page: 7879 year: 2020 ident: 914_CR41 publication-title: Chem. Soc. Rev. doi: 10.1039/D0CS00268B – volume: 25 start-page: 2903 year: 2013 ident: 914_CR44 publication-title: Adv. Mater. doi: 10.1002/adma.201300383 – volume: 5 start-page: 100136 year: 2023 ident: 914_CR46 publication-title: Sens. Actuat Rep. – volume: 37 start-page: 6414 year: 2021 ident: 914_CR4 publication-title: Langmuir doi: 10.1021/acs.langmuir.1c00329 – volume: 91 start-page: 2506 year: 2019 ident: 914_CR39 publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b05375 – volume: 2 start-page: 30 year: 2022 ident: 914_CR11 publication-title: Nat. Rev. Method Prim. doi: 10.1038/s43586-022-00109-7 – volume: 23 start-page: 1169 year: 2023 ident: 914_CR13 publication-title: Lab Chip doi: 10.1039/D2LC00756H – volume: 1254 start-page: 341077 year: 2023 ident: 914_CR32 publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2023.341077 – volume: 12 start-page: 37670 year: 2020 ident: 914_CR24 publication-title: Acs Appl. Mater. Interfaces doi: 10.1021/acsami.0c08179 – volume: 32 start-page: 101638 year: 2023 ident: 914_CR45 publication-title: Mater. Today Chem. doi: 10.1016/j.mtchem.2023.101638 – volume: 6 start-page: 1174 year: 2021 ident: 914_CR38 publication-title: ACS Sens. doi: 10.1021/acssensors.0c02446 – volume: 611 start-page: 570 year: 2022 ident: 914_CR19 publication-title: Nature doi: 10.1038/s41586-022-05408-3 – volume: 6 start-page: eaay5808 year: 2020 ident: 914_CR9 publication-title: Sci. Adv. doi: 10.1126/sciadv.aay5808 – volume: 20 start-page: 789 year: 2020 ident: 914_CR22 publication-title: Lab Chip doi: 10.1039/C9LC01126A – volume: 12 year: 2021 ident: 914_CR21 publication-title: Nat. Commun. doi: 10.1038/s41467-021-27503-1 – volume: 9 start-page: 1155 year: 2017 ident: 914_CR10 publication-title: Acs Appl. Mater. Interfaces doi: 10.1021/acsami.6b09017 – volume: 10 start-page: 166 year: 2020 ident: 914_CR34 publication-title: Biosensors doi: 10.3390/bios10110166 – volume: 5 start-page: 413 year: 2012 ident: 914_CR14 publication-title: Annu Rev. Anal. Chem. doi: 10.1146/annurev-anchem-062011-143028 – volume: 4 start-page: 2181 year: 2019 ident: 914_CR2 publication-title: ACS Sens. doi: 10.1021/acssensors.9b01057 – volume: 17 start-page: 994 year: 2017 ident: 914_CR17 publication-title: Lab Chip doi: 10.1039/C7LC00025A – volume: 7 start-page: 47 year: 2021 ident: 914_CR33 publication-title: Microsyst. Nanoeng. doi: 10.1038/s41378-021-00276-9 – volume: 3 start-page: 8677 year: 2022 ident: 914_CR50 publication-title: Mater. Adv. doi: 10.1039/D2MA00819J – volume: 17 start-page: 23702 year: 2023 ident: 914_CR27 publication-title: Acs Nano doi: 10.1021/acsnano.3c07360 – volume: 121 start-page: 272 year: 2018 ident: 914_CR37 publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2018.08.061 – volume: 117 start-page: 457 year: 2006 ident: 914_CR23 publication-title: Sens. Actuat B: Chem. doi: 10.1016/j.snb.2005.12.053 – volume: 322 start-page: 539 year: 2008 ident: 914_CR7 publication-title: Science doi: 10.1126/science.1165719 – volume: 9 start-page: 1567 year: 2009 ident: 914_CR40 publication-title: Lab Chip doi: 10.1039/b819818g – volume: 396 start-page: 133630 year: 2022 ident: 914_CR47 publication-title: Food Chem. doi: 10.1016/j.foodchem.2022.133630 |
| SSID | ssj0001737905 ssib048324881 |
| Score | 2.3049848 |
| Snippet | Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating droplets.... Abstract Digital microfluidic (DMF) technology is widely used in bioanalysis and chemical reactions due to its accuracy and flexibility in manipulating... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 82 |
| SubjectTerms | 639/166/987 639/638 Cerium oxides Chemical reactions Circuit boards Control systems Droplets Electrochemical analysis Electrodes Electrons Engineering Hydrophobicity Magnetic control Microfluidics Modules Molybdenum disulfide Permanent magnets Silver chloride Three dimensional printing |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT3BAlGdoQUbiBlbjZ-xjqVpVHDhRqTfLr5SVumlFs_-_M052u8tDXLjakTKah-ezPfOZkI99NDHFyJlRTjDA_y1z2OwjAY3z4joApbXK95s5v1BfL_Xl1lNfWBM20QNPijtysG3qARSEzmVlS4q96lSy8Adka4oZV1_IeVubqXq60klknpq7ZFppj-5gtUYyWaEZwAqumNnJRJWw_08o8_diyV9uTGsiOntGns4Ikh5Pku-TR2V4Tp5s8Qq-IP0xneuultgZRZfhasBmRZoXV_hICF1iGV5_vVpkGLy9DiNCV7qhjsgUj2fp_EROmjkFaC5jLdwa6MT__JJcnJ1-Pzln84MKLCmnRhZ5djyHYJIsnUiQ2kvrkslOp94lSOahjRDwMqYkpUi9SKqXWnHrCg8xBvmK7A03Q3lDqBFdtKroxHVS0YrIS4k6WUCTyqhcGvJprVx_O_Fm-HrfLa2fTOHBFL6awpuGfEH9b75Ezus6AJ7gZ0_w__KEhhyurefnQLzzUuAqham6IR820xBCeC8ShnKzqt_gqY61riGvJ2NvJFEtAjINEtodN9gRdXdmWPyoNN1ctMg8pBvyee0xD3L9XRdv_4cuDshjUV1dMy4Oyd74c1XeAXoa4_saKPcfdxe5 priority: 102 providerName: Directory of Open Access Journals – databaseName: Springer Nature OA/Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VcoED4k1oQUbiBhbxM_axrKgqDpyo1JsVP7Ks1M1Wbfb_43GSbRfKgavtSCPPjOeLPfMNwMfOax-8Z1RLy2nG_zW1WOwjMhpnyTYZlJYs3x_67Fx-v1AXB8DnWpiStF8oLcsxPWeHfbnJhy1ywXJFMypgkuoH8BCp29GqF3pxe6_SCOScmupjamHu-XQvBhWq_vvw5d9pkn-8lZYQdPoUnkzYkZyM0j6Dg9Q_h8d3GAVfQHdCpoyrNdZEkXW77LFMkcTVEtuDkDUm4HWX21XMg1eX7YCglexIIyLBi1kyNccJE5sAiWkoKVs9GZmfX8L56befizM6tVKgQVo5UM-iZbFtdRCp4SEH9VTboKNVobMhh_G29tnVhQ9BCB46HmQnlGTGJtZ634pXcNhv-vQGiOaNNzKpwFSQ3nDPUvIqmAaVIWOq4NO8ue5qZMxw5aVbGDeqwmVVuKIKpyv4ivu_W4ls12Vgc710k_adzb_OXQaGbWOjNCn4TjYymGxlyNjlYwXHs_bc5II3TnA8nzBIV_BhN52dB19E2j5ttmUN3ucYYyt4PSp7J4msEYqpLKHZM4M9Ufdn-tWvQtDNeI2cQ6qCz7PF3Mr17714-3_Lj-ARL0atKOPHcDhcb9O7jJAG_764xG_ZPQzC priority: 102 providerName: Springer Nature |
| Title | A programmable magnetic digital microfluidic platform integrated with electrochemical detection system |
| URI | https://link.springer.com/article/10.1038/s41378-025-00914-6 https://www.ncbi.nlm.nih.gov/pubmed/40355456 https://www.proquest.com/docview/3204003413 https://www.proquest.com/docview/3203304889 https://pubmed.ncbi.nlm.nih.gov/PMC12069685 https://doaj.org/article/9274f112a79d48ecbf474c86bc9781bd |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LbxMxELagvcAB8WahREbiBlbXj921TygNDVUEFaJUym21fmwaqdmEJvn_zDhOSnhd1pJtrbyesefb8fgbQt62trTOWs5KZQQD_J8zg5d9JKBxHkwFoDRG-Z6XZ5dqNC7GyeG2TGGV2z0xbtR-7tBHfiwFqhvuuR8WPxhmjcLT1ZRC4y45ROoyDOmqxjtzqkBb1ZYtPfpcKol8VJhvDpA7wwxb6R5NLvXxEt6NdLOiYAA8uGLlnq2KlP5_w6F_hlP-dqYaTdXwIXmQMCbtb5TiEbkTusfk_i_Mg09I26cpMmuGd6forJl0eJ2R-ukE04jQGQbqtdfrqYfKxXWzQnBLd-QSnqIDl6YkOi6xDlAfVjG0q6Mbhuin5HJ4-n1wxlLKBeaUUStmuTfcN03pZKiEA-MfcuNKbwrXGgfmvsktbAnSOielcK1wqpWF4toE3ljbyGfkoJt34QWhpaisVqFwvHDKamF5CLZwGvCmKpUPGXm3ndx6sWHWqOOJuNT1RhQ1iKKOoqjLjJzg_O96Iit2rJjfTOq0yGoDv9gtAMimMl7p4GyrKuU0aCMye1mfkaOt9Oq0VJf1rWJl5M2uGRYZnpw0XZivYx_0-2htMvJ8I-zdSFSOkK2AEeo9Ndgb6n5LN72KRN5c5MhNVGTk_VZjbsf177l4-f_PeEXuiajEBePiiBysbtbhNSCnle3F5QFPPfzUI4f9_uhihOXHL58voDw5Pf_6DVoH5aAXfRM_AYNSG64 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKOQAHxJuUAkaCE0SNH0nsA0LlsWxp6amVejPxI8tK3ey2uyvEn-I3MuMkW5bXrdc4ihzPN_Zne-YbQp7XtrDOWpYWUvMU-H-Wakz2EcDGWdAlkNIY5XtYDI_lp5P8ZIP86HNhMKyynxPjRO2nDs_IdwRHuOGc-2Z2lmLVKLxd7UtotLDYD9-_wZZt_nrvPdj3BeeDD0fvhmlXVSB1UstFapnXzFdV4UQouYP1LWTaFV7nrtYOVrQqs4B6YZ0TgruaO1mLXDKlA6usrQR89wq5KoXQ6FFq8LHHrwTvkL06ezzjKQXqX2F9O9gppFjRq8vbyYTamcO_oLwtz1MgOkymxdraGEsI_I33_hm--dsdblwaB7fIzY7T0t0WhLfJRmjukBu_KB3eJfUu7SLBJpirRSfVqMH0SerHIyxbQicYGFifLsceHs5OqwWSaboSs_AUD4xpV7THdSoH1IdFDCVraKtIfY8cX4ox7pPNZtqEh4QWvLRKhtyx3EmruGUh2Nwp4LeykD4k5GU_uGbWKnmYeAMvlGlNYcAUJprCFAl5i-O_ehNVuOOD6fnIdE5tNGzpayCsVam9VMHZWpbSKUA_KolZn5Dt3nqmmxrm5gLICXm2aganxpuaqgnTZXwHz5mU0gl50Bp71ROZIUXMoYdqDQZrXV1vacZfo3A44xlqIeUJedUj5qJf_x6Lrf__xlNybXj0-cAc7B3uPyLXeQR0njK-TTYX58vwGFjbwj6JrkLJl8v2zZ_OeFIe |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkRAcEG9SChgJTmBt_EhiHxAqlFVLUcWBSnsL8SPLSt3strsrxF_j1zHjJFuW161XO4psz4znsz3zDSHPa5tbZy1nuTKCAf5PmcFkHwlonAdTACiNUb7H-cGJ-jDKRlvkR58Lg2GV_Z4YN2o_c3hHPpAC1Q333EHdhUV82h--mZ8xrCCFL619OY1WRY7C929wfFu8PtwHWb8QYvj-87sD1lUYYE4ZtWSWe8N9VeVOhkI48HUhNS73JnO1ceDdqtSCBUjrnJTC1cKpWmaKaxN4ZW0l4b9XyNVCZhxtrBitXbkCS1E9U3u87ykkcmFhrTs4NTCs7tXl8KRSDxYwL6S6FRkD0MMVyzf8ZCwn8DcM_Gco52_vudFNDm-Rmx2-pXutQt4mW6G5Q278wnp4l9R7tIsKm2LeFp1W4wZTKamfjLGECZ1ikGB9upp4aJyfVksE1nRNbOEpXh7TroCP6xgPqA_LGFbW0Jad-h45uRRh3CfbzawJDwnNRWG1CpnjmVNWC8tDsJnTgHVVrnxIyMt-cct5y-pRxtd4qctWFCWIooyiKPOEvMX1X3-JjNyxYXY-LjsDLw0c72sAr1VhvNLB2VoVymmwBGQVsz4hu730ym6bWJQXSp2QZ-tuMHB8tamaMFvFb_DOSWuTkAetsNcjUSnCxQxGqDfUYGOomz3N5GskEeciRV6kLCGveo25GNe_12Ln_9N4Sq6BVZYfD4-PHpHrIupzxrjYJdvL81V4DABuaZ9ES6Hky2Wb5k9-uVZL |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+programmable+magnetic+digital+microfluidic+platform+integrated+with+electrochemical+detection+system&rft.jtitle=Microsystems+%26+nanoengineering&rft.date=2025-05-12&rft.pub=Springer+Nature+B.V&rft.issn=2096-1030&rft.eissn=2055-7434&rft.volume=11&rft.issue=1&rft.spage=82&rft_id=info:doi/10.1038%2Fs41378-025-00914-6&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2055-7434&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2055-7434&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2055-7434&client=summon |