18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs

• Published in: Journal of pharmaceutical analysis Vol. 12; no. 4; pp. 570 - 582
• Main Authors: Zhang, Qian, Luo, Piao, Zheng, Liuhai, Chen, Jiayun, Zhang, Junzhe, Tang, Huan, Liu, Dandan, He, Xueling, Shi, Qiaoli, Gu, Liwei, Li, Jiahao, Guo, Qiuyan, Yang, Chuanbin, Wong, Yin Kwan, Xia, Fei, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: Xi'an Elsevier B.V 01.08.2022; Xi'an Jiaotong University, Journal of Pharmaceutical Analysis; Artemisinin Research Center and Institute of Chinese Materia Medica,Chinese Academy of Chinese Medical Sciences,Beijing,100700,China; Department of Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University),Shenzhen,518020,China%Department of Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University),Shenzhen,518020,China%Artemisinin Research Center and Institute of Chinese Materia Medica,Chinese Academy of Chinese Medical Sciences,Beijing,100700,China%Department of Biological Sciences,National University of Singapore,Singapore,117543,Singapore; Xi'an Jiaotong University
• Subjects: Acids; Actin; Apoptosis; Chromatography; Collagen; Collagen (type I); Enzymatic activity; Fibrosis; Flow cytometry; Glycyrrhetinic acid; Hepatic fibrosis; Hepatitis; Herbal medicine; Laboratory animals; Liver; Liver diseases; Metabolism; Metabolites; Molecular modelling; Original; Pathogenesis; Peroxiredoxin; Proteins; Reactive oxygen species; Smooth muscle; Stellate cells; Surface plasmon resonance; United States > US; China; Hepatic fibrosis; Peroxiredoxin; Reactive oxygen species; Glycyrrhetinic acid; Apoptosis

Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) is a natural compound that exists widely in herbal medicines, such as Glycyrrhiza uralensis Fisch, which is...