Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis

• Published in: Arthritis research & therapy Vol. 18; no. 1; p. 141
• Main Authors: Gudmann, Natasja Stæhr, Munk, Heidi Lausten, Christensen, Anne Friesgaard, Ejstrup, Leif, Sørensen, Grith Lykke, Loft, Anne Gitte, Karsdal, Morten Asser, Bay-Jensen, Anne-Christine, He, Yi, Siebuhr, Anne Sofie, Junker, Peter
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.06.2016; BioMed Central
• Subjects: Adult; Area Under Curve; Arthritis; Arthritis, Psoriatic - metabolism; Arthritis, Psoriatic - pathology; Biomarkers - blood; Cartilage cells; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Chondrocytes - metabolism; Chondrocytes - pathology; Collagen Type II - analysis; Collagen Type II - blood; Collagen Type X - analysis; Collagen Type X - blood; Development and progression; Enzyme-Linked Immunosorbent Assay; Female; Genetic aspects; Humans; Male; Physiological aspects; Psoriatic arthritis; ROC Curve; Sensitivity and Specificity; Spondylarthritis - metabolism; Spondylarthritis - pathology; Denmark; Pro-C2; C-Col10; Type X collagen; Type II collagen; Spondyloarthritis; Psoriatic arthritis

Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both are characterized by altered extracellular matrix remodeling in joints and entheses that results in destructive and osteochondral proliferative lesions. There is a nee...