Serum sphingomyelin levels define oxyhemoglobin desaturation-related metabolic threshold in symptomatic obstructive sleep apnea

• Published in: Scientific reports Vol. 15; no. 1; pp. 12533 - 8
• Main Authors: Kiens, Ott, Taalberg, Egon, Ivanova, Viktoria, Veeväli, Ketlin, Laurits, Triin, Tamm, Ragne, Ottas, Aigar, Kilk, Kalle, Soomets, Ursel, Altraja, Alan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.04.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/45/320; 692/699/1785; Adult; Aged; Amines; Apnea; Biogenic amines; Chromatography; Female; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia - blood; Liquid chromatography; Male; Metabolism; Metabolites; Metabolome; Metabolomic threshold; Middle Aged; Morbidity; multidisciplinary; Observational studies; Obstructive sleep apnea; Oxyhemoglobins - metabolism; Peripheral blood; Polysomnography; Prospective Studies; Science; Science (multidisciplinary); Sleep apnea; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - metabolism; Sleep disorders; Spectrometry; Sphingomyelin; Sphingomyelins - blood; Metabolome; Hypoxia; Metabolomic threshold; Metabolism; Obstructive sleep apnea

Hypoxia is a contributing factor for the morbidity and mortality in patients with obstructive sleep apnea (OSA). We aimed at identifying the percentage of sleep time with oxyhemoglobin desaturation below 90% (Tc90%) breakpoint from which the most significant changes occur in systemic metabolome of p...