Enantioselective dearomative ortho-cycloaddition transformation of unactivated arenes by cage-confined visible-light photocatalysis

• Published in: Nature communications Vol. 16; no. 1; pp. 3980 - 12
• Main Authors: Yang, Jie, Li, Zhongshu, Wu, Xiantao, Chen, Jie, Huang, Sisi, Lu, Yu-Lin, Jiao, Zhiwei, Su, Cheng-Yong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.04.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/131; 140/58; 639/638/439/890; 639/638/541/965; 639/638/77/883; 639/638/77/890; Aromatic compounds; Aromaticity; Asymmetry; Cages; Carbon; Chirality; Cycloaddition; Enantiomers; Energy transfer; Enzymes; Humanities and Social Sciences; Light; Microenvironments; Mimicry; multidisciplinary; Photocatalysis; Science; Science (multidisciplinary); Self-assembly; Solvents

Photoinduced dearomatization of arenes is a powerful strategy in organic synthesis to disrupt the stable aromaticity; however, the asymmetric dearomatization photocatalysis of unactivated arenes remains highly challenging and rare. Herein we demonstrate an enzyme-mimicking cage-confined visible-ligh...