ANGPTL4 promoted the cognitive impairment in vascular dementia via increasing integrin/p-Syk signalings induced mitochondrial autophagy and apoptosis in the hippocampus - Yao, Chunhong; Wang, Jinfeng (Scientific reports, 2025)
Keywords: 631/80; 692/308; Angiopoietin-Like Protein 4 - genetics; Angiopoietin-Like Protein 4 - metabolism; ANGPTL4; Animals; Apoptosis; Autophagy; Biotechnology; BNIP3 protein; Carotid arteries; Carotid artery; Cognitive ability; Cognitive Dysfunction - etiology; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Dementia; Dementia disorders; Dementia, Vascular - metabolism; Dementia, Vascular - pathology; Disease Models, Animal; Experiments; Genes; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Humanities and Social Sciences; Immunohistochemistry; JNK protein; Kinases; Male; Membrane potential; Membrane Proteins - metabolism; Memory; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial autophagy; Mitochondrial Proteins; multidisciplinary; p-JNK; p-Syk; Pathogenesis; Proteins; PTEN-induced putative kinase; Rats; Rats, Sprague-Dawley; Science; Science (multidisciplinary); Signal Transduction; Spatial memory; Stains & staining; Syk Kinase - metabolism; Syk protein; Vascular dementia; Veins & arteries; China; Shanghai China; p-Syk; Vascular dementia; ANGPTL4; Mitochondrial autophagy; p-JNK