Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation

• Published in: Journal of hepatology Vol. 77; no. 5; pp. 1246 - 1255
• Main Authors: Tripathi, Madhulika, Singh, Brijesh Kumar, Zhou, Jin, Tikno, Keziah, Widjaja, Anissa, Sandireddy, Reddemma, Arul, Kabilesh, Abdul Ghani, Siti Aishah Binte, Bee, George Goh Boon, Wong, Kiraely Adam, Pei, Ho Jia, Shekeran, Shamini Guna, Sinha, Rohit Anthony, Singh, Manvendra K., Cook, Stuart Alexander, Suzuki, Ayako, Lim, Teegan Reina, Cheah, Chang-Chuen, Wang, Jue, Xiao, Rui-Ping, Zhang, Xiuqing, Chow, Pierce Kah Hoe, Yen, Paul Michael
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2022
• Subjects: Autophagy; B12; Fibrosis; Folate; Homocysteine; Non-alcoholic steatohepatitis (NASH); Protein homocysteinylation; Syntaxin-17; Vitamin therapy; Vitamin therapy; Syntaxin-17; B12; Fibrosis; Homocysteine; Autophagy; Folate; Protein homocysteinylation; Non-alcoholic steatohepatitis (NASH)

Several recent clinical studies have shown that serum homocysteine (Hcy) levels are positively correlated, while vitamin B12 (B12) and folate levels are negative correlated, with non-alcoholic steatohepatitis (NASH) severity. However, it is not known whether hyperhomocysteinemia (HHcy) plays a patho...