Paradigm shift in the role of uric acid in acute kidney injury

It has been known for decades that uric acid causes acute kidney injury by intratubular crystal precipitation and obstructing the renal tubules. Uric acid crystals stimulate inflammation and elicit immune responses in many disease conditions, including gouty arthritis. More recently, soluble uric ac...

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Bibliographic Details
Published inSeminars in nephrology Vol. 31; no. 5; p. 453
Main Authors Shimada, Michiko, Dass, Bhagwan, Ejaz, A Ahsan
Format Journal Article
LanguageEnglish
Published United States 01.09.2011
Subjects
Acute Kidney Injury - etiology
Humans
Uric Acid - metabolism
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Summary:It has been known for decades that uric acid causes acute kidney injury by intratubular crystal precipitation and obstructing the renal tubules. Uric acid crystals stimulate inflammation and elicit immune responses in many disease conditions, including gouty arthritis. More recently, soluble uric acid has been reported to stimulate proliferation of vascular smooth muscle cells, inhibit endothelial function, cause renal vasoconstriction, impair renal blood flow autoregulation, and induce inflammatory response via crystal-independent mechanisms. This article examines the changing role for uric acid in acute kidney injury.
ISSN:1558-4488
DOI:10.1016/j.semnephrol.2011.08.010