Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach

• Published in: The Journal of nutritional biochemistry Vol. 23; no. 2; pp. 133 - 139
• Main Authors: He, Qinghua, Ren, Pingping, Kong, Xiangfeng, Wu, Yongning, Wu, Guoyao, Li, Peng, Hao, Fuhua, Tang, Huiru, Blachier, François, Yin, Yulong
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2012; Elsevier
• Subjects: adolescents; Agricultural sciences; amino acid metabolism; Analysis; Animal subjects; Animals; Biological and medical sciences; Blood; blood glucose; Blood Glucose - analysis; Body Composition; childhood obesity; children; choline; Choline - blood; creatine; diet; digestive system; discriminant analysis; energy; Feeding. Feeding behavior; fermentation; Fundamental and applied biological sciences. Psychology; glucagon; Glucagon - blood; glycoproteins; high density lipoprotein; insulin; Insulin - blood; Lean pigs; Life Sciences; Lipid Metabolism; lipid peroxidation; Lipids; Lipoproteins, HDL; Lipoproteins, HDL - blood; Lipoproteins, VLDL; Lipoproteins, VLDL - blood; Magnetic Resonance Spectroscopy; Magnetic Resonance Spectroscopy - methods; Metabolism; metabolites; Metabolomics; Metabonomics; methods; Methylamines; Methylamines - blood; microorganisms; Multivariate Analysis; Muscles (size); myo-inositol; Obese pigs; Obesity; Obesity - blood; Obesity - metabolism; Proteins; pyruvic acid; risk; Serum; Strains; swine; Swine - blood; Swine - metabolism; threonine; tyrosine; urea; Vertebrates: anatomy and physiology, studies on body, several organs or systems; very low density lipoprotein; TMAO; 1DOPLS-DA; Obesity; DLL; TOCSY; COSY; PCA; Lean pigs; HDL; Obese pigs; NMR; RD; 1D; LDL; VLDL; Metabonomics; CPMG; Serum; BPP-LED; Metabolite; Nutrition disorder; Pig; Vertebrata; Mammalia; Artiodactyla; Ungulata; Nutritional status; Comparative study; H-1-NMR SPECTROSCOPY; MULTIVARIATE DATA-ANALYSIS; PHENOTYPES; SUPPLEMENTATION; PLASMA; INSULIN-RESISTANCE; AMINO-ACIDS; ANIMAL-MODELS; CHILDHOOD OBESITY; DIABETIC FATTY RATS

Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean (Duroc×Landrace×Large Yorkshire strain) growing pigs were used as models to identify potential differences in...