Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture - Rivera-Torres, José; Acín-Perez, Rebeca; Cabezas-Sánchez, Pablo; Osorio, Fernando G.; Gonzalez-Gómez, Cristina; Megias, Diego; Cámara, Carmen; López-Otín, Carlos; Enríquez, José Antonio; Luque-García, José L.; Andrés, Vicente (Journal of proteomics, 2013)
Keywords: Accelerated aging; Adenosine Triphosphate; Adenosine Triphosphate - chemistry; Adolescent; adults; amino acids; Amino Acids - chemistry; analogs & derivatives; animal models; Animals; brain; cell culture; chemistry; Child; clinical trials; Diphosphonates; Diphosphonates - chemistry; drugs; Female; fibroblasts; Fibroblasts - metabolism; Galactose; Galactose - metabolism; Gene Expression Regulation; genes; Glucose; Glucose - chemistry; glycolysis; H-transporting ATP synthase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry; Imidazoles; Imidazoles - chemistry; isotope labeling; Lamin A; Lamin Type A; Male; metabolism; Methionine; Methionine - analogs & derivatives; Methionine - chemistry; Mice; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial dysfunction; Molecular biology of aging; mutants; Mutation; Nuclear Proteins; Nuclear Proteins - chemistry; oxidative phosphorylation; Oxygen Consumption; pathology; patients; point mutation; Pravastatin; Pravastatin - chemistry; Progeria; Progeria - metabolism; Progerin; Protein Precursors; Protein Precursors - chemistry; protein synthesis; proteins; proteome; Proteomics; senescence; SILAC; Skin; Skin - metabolism; stable isotopes; toxicity; Zoledronic Acid; Molecular biology of aging; p70S6K; ATP5A1; ATP5C1; OXPHOS; ATP5O; ENO2; ATP5B; Zmpste24; mTOR; eIF4; eIF2; FpSDH; HGPS; Mitochondrial dysfunction; Progerin; SILAC; ATP5F1; COX; Lamin A; CS; MAF; PKM; Accelerated aging; FTI