Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors

• Published in: Nature medicine Vol. 16; no. 6; pp. 694 - 700
• Main Authors: Murray, Katherine C, Nakae, Aya, Stephens, Marilee J, Rank, Michelle, D'Amico, Jessica, Harvey, Philip J, Li, Xiaole, Harris, R Luke W, Ballou, Edward W, Anelli, Roberta, Heckman, Charles J, Mashimo, Takashi, Vavrek, Romana, Sanelli, Leo, Gorassini, Monica A, Bennett, David J, Fouad, Karim
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2010; Nature Publishing Group
• Subjects: 631/378/1687/1825; 631/378/2632/1664; 631/92/612/194; Animals; Biomedical and Life Sciences; Biomedicine; Calcium; Calcium - physiology; Cancer Research; Female; Humans; Infectious Diseases; Locomotion - physiology; Membrane Potentials - physiology; Metabolic Diseases; Molecular Medicine; Motor Neurons - physiology; Neurosciences; Neurotransmitters; Paralysis; Protein Isoforms - physiology; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C - physiology; Receptors, Serotonin, 5-HT2 - physiology; Rodents; Serotonin - physiology; Spasm - physiopathology; Spinal cord injuries; Spinal Cord Injuries - physiopathology; Up-Regulation - physiology

Spinal cord injury leads to flaccid paralysis resulting from the loss of descending serotonergic modulation. Murray et al . demonstrate that spontaneous recovery of motoneuron excitability is associated with alternative mRNA editing and increased expression of constitutively active 5HT 2C serotonin...