Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study

• Published in: Scientific reports Vol. 15; no. 1; pp. 11149 - 11
• Main Authors: Liang, Jing-hua, Wang, Leng-meng, Song, Shu-fen, Yu, Cong, Chen, Xing-lin, Yu, Jin-rong, Chen, Ya-ling, Xia, Hu-lu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163; 692/53; 692/699; Aged; Blood; Blood Glucose - analysis; Blood Glucose - metabolism; Blood Urea Nitrogen; Cohort analysis; Cohort Studies; Critical Illness - mortality; Critically ill patients; Female; Humanities and Social Sciences; Humans; Insulin resistance; Intensive Care Units; Male; Mediation; Middle Aged; Mortality; Mortality risk; multidisciplinary; Nitrogen; Prognosis; Proportional Hazards Models; Retrospective Studies; Science; Science (multidisciplinary); Triglyceride glucose index; Triglycerides - blood; Prognosis; Mortality; Critically ill patients; Triglyceride glucose index; Blood urea nitrogen; Insulin resistance; Mediation

Previous studies have shown that an elevated triglyceride-glucose (TyG) index is associated with all-cause mortality in patients. However, the potential mediating effect of blood urea nitrogen (BUN) within these associations has not been reported. The focus of this study was to investigate the poten...