Clinical Challenge of Two Competing Targetable Mutations in Non-Small-Cell Lung Cancer: A Case Report

• Published in: Diagnostics (Basel) Vol. 13; no. 19; p. 3112
• Main Authors: Park, Sonya Youngju, Yoon, Hyukjin, Han, Eun Ji, Yoo, Ie Ryung
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023; MDPI
• Subjects: ALK; Cancer; Cancer therapies; Care and treatment; Case reports; Conflicts of interest; Crizotinib; EGFR; Epidermal growth factor; FDG PET/CT; Gene mutations; Genetic aspects; Health aspects; Interesting Images; Kinases; Lung cancer; Lung cancer, Non-small cell; Metastasis; Mutation; Non-Hodgkin's lymphomas; non-small-cell lung cancer; Patients; Phosphorylation; Review boards; Tumors

The development of therapeutic agents targeting products of epidermal growth factor receptor (EGFR) gene mutation and anaplastic lymphoma kinase (ALK) rearrangements has improved survival in patients with non-small-cell lung cancer. EGFR and ALK mutations are generally regarded as mutually exclusive...